An enantioselective total synthesis of (+)-picrasin B

Kenji Kawada, Moonsun Kim, David S. Watt

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


An enantioselective total synthesis of (+)-picrasin B (1) from the R-(-)-enantiomer of the Wieland-Miescher ketone (4) employed an A-AB-ABC-ABCD sequence to assemble the tetracyclic skeleton and relied upon a free radical cyclization of an α-bromoacetal to an enone in order to introduce the D ring and a manganese(III) acetate oxidation of a tricyclic enone intermediate in order to introduce the C-11 oxygen substituent.

Original languageEnglish
Pages (from-to)5989-5992
Number of pages4
JournalTetrahedron Letters
Issue number44
StatePublished - 1989

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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