An evaluation of antigen-driven expansion and differentiation of hapten-specific B lymphocytes purified from aged mice

E. C. Snow

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Hapten-specific, trinitrophenyl antigen-binding B cells (TNP-ABC) were purified from inbred strains of mice representative of short-, intermediate-, and long-lived animals. Such populations of B cells were stimulated by either thymus-independent or thymus-dependent antigens in vitro and evaluated for both proliferation and differentiation into antibody-secreting cells. In the thymus-dependent system, the three strains of mice were selected on the basis of all being able to interact appropriately with the same T helper cell line. The results indicate that TNP-ABC purified from aged animals of all three strains responded to both forms of antigenic stimulation similar to TNP-ABC selected from young, littermate control animals. These results are discussed in terms of concepts of intrinsic B cell defects during the aging process.

Original languageEnglish
Pages (from-to)1758-1762
Number of pages5
JournalJournal of Immunology
Volume139
Issue number6
StatePublished - 1987

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint

Dive into the research topics of 'An evaluation of antigen-driven expansion and differentiation of hapten-specific B lymphocytes purified from aged mice'. Together they form a unique fingerprint.

Cite this