An imidazopyridinone and further metabolites from streptomycetes [1]

Hafizur Rahman, Mohamed Shaaban, Khaled A. Shaaban, Muhammad Saleem, Elisabeth Helmke, Iris Grün-Wollny, Hartmut Laatsch

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Screening and chromatographic analysis of the extracts from the terrestrial streptomycete GW5127 and from the marine Streptomyces sp. isolate B7967 yielded four new metabolites, i.e. 8-ethyl-6,11-dihydroxy-1-methoxy-naphthacene-5,12- dione (1a), 4-acetyl-1,3-dihydro-imidazo[4,5-c]pyridin-2-one (4a), 5-hydroxmethyl-4-hydroxy-2,4-dimethyl-2-cyclopentenone (6), and N-[2-(3′-hydroxy-4′-methoxyphenyl)-ethyl]-acetamide (5a), along with five known compounds, α-rubromycin (2), γ-rubromycin (3), 2-(3′-hydroxy-4′-methoxyphenyl)ethanol (5b), uracil, and N-acetyltyramine. The structures of the new compounds were deduced from high resolution mass, 1D and 2D NMR spectra and by comparison with related compounds from the literature. The antibiotic activity of the crude extracts was due to 2 and 3.

Original languageEnglish
Pages (from-to)965-970
Number of pages6
JournalNatural Product Communications
Volume4
Issue number7
DOIs
StatePublished - 2009

Keywords

  • Imidazolone
  • Marine streptomycetes

ASJC Scopus subject areas

  • Drug Discovery
  • Complementary and alternative medicine
  • Plant Science
  • Pharmacology

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