Abstract
Abstract: A modified filtration method for in vitro receptor binding was used to determine specific binding of [3H]naloxone to small regions of adult rat brain. Reliable determinations of ligand binding were quantified with about 50 μg of protein per assay tube. Large differences in [3H]naloxone binding were obtained between various brain nuclei, and these differences were consistent with prior determinations of opiate receptor densities in various rat brain nuclei using autoradiographic techniques.
| Original language | English |
|---|---|
| Pages (from-to) | 1751-1754 |
| Number of pages | 4 |
| Journal | Journal of Neurochemistry |
| Volume | 39 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 1982 |
Funding
| Funders | Funder number |
|---|---|
| National Institute on Drug Abuse | R37DA002879 |
Keywords
- Brain nuclei
- Naloxone
- Opiate receptor
ASJC Scopus subject areas
- Biochemistry
- Cellular and Molecular Neuroscience
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