An emerging class of models has been developed in recent years to predict cardiac growth and remodeling (G&R). We recently developed a cardiac G&R constitutive model that predicts remodeling in response to elevated hemodynamics loading, and a subsequent reversal of the remodeling process when the loading is reduced. Here, we describe the integration of this G&R model to an existing strongly coupled electromechanical model of the heart. A separation of timescale between growth deformation and elastic deformation was invoked in this integrated electromechanical-growth heart model. To test our model, we applied the G&R scheme to simulate the effects of myocardial infarction in a realistic left ventricular (LV) geometry using the finite element method. We also simulate the effects of a novel therapy that is based on alteration of the infarct mechanical properties. We show that our proposed model is able to predict key features that are consistent with experiments. Specifically, we show that the presence of a non-contractile infarct leads to a dilation of the left ventricle that results in a rightward shift of the pressure volume loop. Our model also predicts that G&R is attenuated by a reduction in LV dilation when the infarct stiffness is increased.
|Number of pages||13|
|Journal||Biomechanics and Modeling in Mechanobiology|
|State||Published - Aug 1 2016|
Bibliographical noteFunding Information:
This work was supported by the Marie Curie International Outgoing Fellowship within the 7th European Community Framework Program (M. Genet) and a grant from the American Heart Association 14BGIA18850020 (J.F. Wenk).
© 2015, Springer-Verlag Berlin Heidelberg.
- Bioinjection therapy
- Cardiac electromechanics
- Finite element modeling
- Growth and remodeling
- Myocardial infarction
ASJC Scopus subject areas
- Modeling and Simulation
- Mechanical Engineering