An integrative U method for joint analysis of multi-level omic data

Pei Geng, Xiaoran Tong, Qing Lu

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Background: The advance of high-throughput technologies has made it cost-effective to collect diverse types of omic data in large-scale clinical and biological studies. While the collection of the vast amounts of multi-level omic data from these studies provides a great opportunity for genetic research, the high dimensionality of omic data and complex relationships among multi-level omic data bring tremendous analytic challenges. Results: To address these challenges, we develop an integrative U (IU) method for the design and analysis of multi-level omic data. While non-parametric methods make less model assumptions and are flexible for analyzing different types of phenotypes and omic data, they have been less developed for association analysis of omic data. The IU method is a nonparametric method that can accommodate various types of omic and phenotype data, and consider interactive relationship among different levels of omic data. Through simulations and a real data application, we compare the IU test with commonly used variance component tests. Conclusions: Results show that the proposed test attains more robust type I error performance and higher empirical power than variance component tests under various types of phenotypes and different underlying interaction effects.

Original languageEnglish
Article number40
JournalBMC Genetics
Issue number1
StatePublished - Apr 10 2019

Bibliographical note

Publisher Copyright:
© 2019 The Author(s).


  • Functional data analysis
  • Integrative analysis
  • Non-parametric method

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)


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