An interim screening limit of detection for naproxen in equine plasma: A review and analysis

J. Machin, K. Brewer, M. Catignani, T. F. Shults, C. Fenger, G. A. Maylin, T. Tobin

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Starting in August 2015 Thoroughbred racing in Charles Town, West Virginia experienced a sequence of intermittent low concentration Naproxen identifications from 6.3 to 161 ng/ml of plasma (27.3 to 699 nM). These identifications were ongoing, indicating the horsemen were unaware of their origins. Naproxen is administered orally to horses at substantial doses and is chemically stable in the environment. These identifications are therefore most likely associated with exposure of these horses to environmental traces of Naproxen. Given the low concentrations of these identifications, we were asked to identify a Screening Limit of Detection (SLOD) below which these trace level Naproxen identifications would not be reported. Review of the data set suggested an SLOD of 200 ng/ml, while outlier analysis suggested an 'extreme' outlier level at 247 ng/ml, which figure was rounded up to 250 ng/ml Naproxen or 1.09 uM. This proposed SLOD is in good agreement with other US regulatory thresholds for therapeutic medications and this Interim Screening Limit of Detection was presented for review.

Original languageEnglish
Pages (from-to)153-160
Number of pages8
JournalComparative Exercise Physiology
Volume16
Issue number2
DOIs
StatePublished - 2020

Bibliographical note

Publisher Copyright:
© 2019 Wageningen Academic Publishers.

Keywords

  • Clinical practice
  • Environmental substance
  • Horseracing
  • Naproxen
  • Screening limit of detection

ASJC Scopus subject areas

  • Biophysics
  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Physiology
  • Orthopedics and Sports Medicine
  • Veterinary (miscellaneous)
  • Physiology (medical)

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