Abstract
Starting in August 2015 Thoroughbred racing in Charles Town, West Virginia experienced a sequence of intermittent low concentration Naproxen identifications from 6.3 to 161 ng/ml of plasma (27.3 to 699 nM). These identifications were ongoing, indicating the horsemen were unaware of their origins. Naproxen is administered orally to horses at substantial doses and is chemically stable in the environment. These identifications are therefore most likely associated with exposure of these horses to environmental traces of Naproxen. Given the low concentrations of these identifications, we were asked to identify a Screening Limit of Detection (SLOD) below which these trace level Naproxen identifications would not be reported. Review of the data set suggested an SLOD of 200 ng/ml, while outlier analysis suggested an 'extreme' outlier level at 247 ng/ml, which figure was rounded up to 250 ng/ml Naproxen or 1.09 uM. This proposed SLOD is in good agreement with other US regulatory thresholds for therapeutic medications and this Interim Screening Limit of Detection was presented for review.
| Original language | English |
|---|---|
| Pages (from-to) | 153-160 |
| Number of pages | 8 |
| Journal | Comparative Exercise Physiology |
| Volume | 16 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2020 |
Bibliographical note
Publisher Copyright:© 2019 Wageningen Academic Publishers.
Funding
Published as paper #500 from T Tobin and the Equine Pharmacology, Therapeutics and Toxicology Program at the Maxwell H. Gluck Equine Research Center and Department of Veterinary Science, University of Kentucky. The information reported in this paper is part of a project of the Kentucky Agricultural Experiment Station (KAES publication # 15-14-036) and is published with the approval of the Director. This research was supported by grants from the USDA Agriculture Research Service Specific Cooperative Agreement #58-6401-2-0025 for Forage-Animal Production Research, the Kentucky Department of Agriculture and the Kentucky Thoroughbred Association Foundation and by support for the Kentucky Agricultural Experiment Station as provided by the National Institute of Food and Agriculture (NIFA) and the Commonwealth of Kentucky. Other support that has made this work possible includes research support from The National Horsemen’s Benevolent and Protective Association and the Alabama; Arizona; Arkansas; Ontario, Canada; Charles Town, WV; Florida; Indiana, Iowa; Kentucky; Louisiana; Michigan; Minnesota, Nebraska, Ohio, Oklahoma, Ontario Canada, Oregon, Pennsylvania, Tampa Bay Downs, Florida; Texas; Washington State; and West Virginia Horsemen’s Benevolent and Protective Associations, the Equine Health and Welfare Alliance, Incorporated, Versailles, Kentucky and Mrs. John Hay Whitney.
| Funders | Funder number |
|---|---|
| COMMONWEALTH OF KENTUCKY | |
| Kentucky Department of Agriculture | |
| Kentucky Thoroughbred Association Foundation | |
| Kentucky and Mrs. John Hay Whitney | |
| National Horsemen’s | |
| West Virginia Horsemen’s | |
| US Department of Agriculture National Institute of Food and Agriculture, Agriculture and Food Research Initiative | |
| USDA-Agricultural Research Service | 58-6401-2-0025 |
| USDA-Agricultural Research Service | |
| Kentucky Agricultural Experiment Station |
Keywords
- Clinical practice
- Environmental substance
- Horseracing
- Naproxen
- Screening limit of detection
ASJC Scopus subject areas
- Biophysics
- Endocrinology, Diabetes and Metabolism
- Biochemistry
- Physiology
- Orthopedics and Sports Medicine
- Veterinary (miscellaneous)
- Physiology (medical)
