An unusual Alu repeat sequence within the CAD gene

Jeffrey N. Davidson, Nada H. Khattar, Kuey Chu Chen

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


There are several hundred thousand members of the Alu repeat family in the human genome. Those Alu elements sequenced to date appear to fit into subfamilies. A novel Alu has been found in an intron of the human CAD gene: it appears to be due to rearrangement between Alu repeats belonging to two different subfamilies. Further sequence data from this intron suggest that the Alu element may have rearranged prior to its entry into the CAD gene. Such findings indicate that, in addition to single nucleotide substitutions and deletions, DNA rearrangments may be a factor in generating the diversity of Alu repeats found in primate genomes.

Original languageEnglish
Pages (from-to)162-166
Number of pages5
JournalJournal of Molecular Evolution
Issue number2
StatePublished - Feb 1991


  • Alu family evolution
  • Subfamily rearrangement

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics


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