Anabolic and catabolic pathways regulating skeletal muscle mass

John J. McCarthy, Karyn A. Esser

Research output: Contribution to journalReview articlepeer-review

104 Scopus citations


Purpose of review: The purpose of this review is to discuss Recent findings: as they pertain to anabolic and catabolic-signaling pathways involved in the regulation of adult skeletal muscle mass. Recent findings: Research conducted over the past few years has continued to refine our understanding of the pathways that govern skeletal muscle mass, in particular the mTOR, FoxO and NF-κB pathways. Alternative signaling pathways have also emerged as important regulators of muscle mass such as the β-catenin pathway. Summary: A better understanding of the anabolic and catabolic processes which regulate skeletal muscle mass is critical for the development of more effective therapeutics to prevent the loss of muscle with disuse, aging and disease.

Original languageEnglish
Pages (from-to)230-235
Number of pages6
JournalCurrent Opinion in Clinical Nutrition and Metabolic Care
Issue number3
StatePublished - May 2010


  • Anabolic
  • Catabolic
  • MTOR
  • NF-κB
  • Skeletal muscle

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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