Anabolic and Catabolic Signaling Pathways That Regulate Skeletal Muscle Mass

John J. McCarthy, Kevin A. Murach

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

7 Scopus citations

Abstract

Skeletal muscle mass is primarily dictated by the balance between the rates of protein synthesis and degradation. Over the last decade, significant progress has been made in defining the anabolic and catabolic signaling pathways that control skeletal muscle mass through the regulation of protein synthesis and degradation. The purpose of this review is to briefly describe known and emerging signaling pathways involved in the regulation of skeletal muscle mass. Two important themes have come to light: (1) the degree of cross talk between and among anabolic and catabolic signaling pathways involved in the control of skeletal muscle hypertrophy and atrophy and (2) the balance between anabolism and catabolism that is required to facilitate a proper hypertrophic response. A more in-depth understanding of the anabolic and catabolic signaling pathways that regulate skeletal muscle mass will provide a critical foundation for the development of more effective training programs and nutritional aids to enhance athletic performance.

Original languageEnglish
Title of host publicationNutrition and Enhanced Sports Performance
Subtitle of host publicationMuscle Building, Endurance, and Strength
Pages275-290
Number of pages16
DOIs
StatePublished - Oct 10 2018

Keywords

  • AMPK
  • Anabolic
  • Atrophy
  • Catabolic
  • FOXO
  • Hypertrophy
  • MAFbx
  • Mechanotransduction
  • MuRF1
  • Myostatin
  • NF-κB
  • Nitric oxide
  • PGC-1α4
  • Ribosome biogenesis
  • TORC1
  • TRPV1
  • YAP/TAZ
  • β-Adrenergic
  • β-Catenin

ASJC Scopus subject areas

  • Engineering (all)
  • Agricultural and Biological Sciences (all)

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