Analysis of alloantisera against bovine lymphocytes. Joint report of the 1st International Bovine Lymphocyte Antigen (BoLA) Workshop

R. L. Spooner; R. A. Oliver; D. I. Sales; C. M. McCoubrey; P. Millar; A. G. Morgan; B. Amorena; E. Bailey; D. Bernoco; M. Brandon; R. W. Bull; J. Caldwell; S. Cwik; R. H. van Dam; J. Dodd; B. Gahne; F. Grosclaude; J. G. Hall; H. Hines; H. Leveziel; M. J. Newman; M. J. Stear; W. H. Stone; M. Vaiman

doi:10.1111/j.1365-2052.1979.tb01009.x

Analysis of alloantisera against bovine lymphocytes. Joint report of the 1st International Bovine Lymphocyte Antigen (BoLA) Workshop

R. L. Spooner, R. A. Oliver, D. I. Sales, C. M. McCoubrey, P. Millar, A. G. Morgan, B. Amorena, E. Bailey, D. Bernoco, M. Brandon, R. W. Bull, J. Caldwell, S. Cwik, R. H. van Dam, J. Dodd, B. Gahne, F. Grosclaude, J. G. Hall, H. Hines, H. LevezielM. J. Newman, M. J. Stear, W. H. Stone, M. Vaiman

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Abstract

The results and agreements of the 1st international BoLA workshop, held in Edinburgh, Scotland in August 1978, are reported. Most of these concern the results from a comparison test of 249 alloantisera to bovine lymphocytes, the antisera being contributed by 9 laboratories. These sera were compared directly in Edinburgh on a panel of lymphocytes from 130 cattle of 21 breeds. In the micro‐lymphocytotoxicity test used 75% of the sera reacted. Sixty eight of these sera were grouped into clusters according to their reaction patterns against the lymphocyte panel. Eleven of these clusters were clearly defined and were given workshop BoLA designations. In addition 22 sera were assigned to subgroups of the agreed clusters. There was no evidence that the method of production of the sera had any effect on their specificity. Although genetic data was not available, the phenotypes of the test panel of lymphocytes are consistent with the clusters detecting antigens controlled by multiple alleles at a single autosomal locus. It was agreed to name the genetic region where this putative locus is located BoLA (bovine lymphocyte antigen).

Original language	English
Pages (from-to)	63-86
Number of pages	24
Journal	Animal Blood Groups and Biochemical Genetics
Volume	10
Issue number	2
DOIs	https://doi.org/10.1111/j.1365-2052.1979.tb01009.x
State	Published - Apr 1979

Keywords

BoLA
MHS
bovine lymphocyte antigen
cattle
comparison test
major histocompatibility system

ASJC Scopus subject areas

Animal Science and Zoology
Genetics

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10.1111/j.1365-2052.1979.tb01009.x

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Spooner, R. L., Oliver, R. A., Sales, D. I., McCoubrey, C. M., Millar, P., Morgan, A. G., Amorena, B., Bailey, E., Bernoco, D., Brandon, M., Bull, R. W., Caldwell, J., Cwik, S., van Dam, R. H., Dodd, J., Gahne, B., Grosclaude, F., Hall, J. G., Hines, H., ... Vaiman, M. (1979). Analysis of alloantisera against bovine lymphocytes. Joint report of the 1st International Bovine Lymphocyte Antigen (BoLA) Workshop. Animal Blood Groups and Biochemical Genetics, 10(2), 63-86. https://doi.org/10.1111/j.1365-2052.1979.tb01009.x

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title = "Analysis of alloantisera against bovine lymphocytes. Joint report of the 1st International Bovine Lymphocyte Antigen (BoLA) Workshop",

abstract = "The results and agreements of the 1st international BoLA workshop, held in Edinburgh, Scotland in August 1978, are reported. Most of these concern the results from a comparison test of 249 alloantisera to bovine lymphocytes, the antisera being contributed by 9 laboratories. These sera were compared directly in Edinburgh on a panel of lymphocytes from 130 cattle of 21 breeds. In the micro‐lymphocytotoxicity test used 75% of the sera reacted. Sixty eight of these sera were grouped into clusters according to their reaction patterns against the lymphocyte panel. Eleven of these clusters were clearly defined and were given workshop BoLA designations. In addition 22 sera were assigned to subgroups of the agreed clusters. There was no evidence that the method of production of the sera had any effect on their specificity. Although genetic data was not available, the phenotypes of the test panel of lymphocytes are consistent with the clusters detecting antigens controlled by multiple alleles at a single autosomal locus. It was agreed to name the genetic region where this putative locus is located BoLA (bovine lymphocyte antigen).",

keywords = "BoLA, MHS, bovine lymphocyte antigen, cattle, comparison test, major histocompatibility system",

author = "Spooner, {R. L.} and Oliver, {R. A.} and Sales, {D. I.} and McCoubrey, {C. M.} and P. Millar and Morgan, {A. G.} and B. Amorena and E. Bailey and D. Bernoco and M. Brandon and Bull, {R. W.} and J. Caldwell and S. Cwik and {van Dam}, {R. H.} and J. Dodd and B. Gahne and F. Grosclaude and Hall, {J. G.} and H. Hines and H. Leveziel and Newman, {M. J.} and Stear, {M. J.} and Stone, {W. H.} and M. Vaiman",

year = "1979",

month = apr,

doi = "10.1111/j.1365-2052.1979.tb01009.x",

language = "English",

volume = "10",

pages = "63--86",

number = "2",

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Spooner, RL, Oliver, RA, Sales, DI, McCoubrey, CM, Millar, P, Morgan, AG, Amorena, B, Bailey, E, Bernoco, D, Brandon, M, Bull, RW, Caldwell, J, Cwik, S, van Dam, RH, Dodd, J, Gahne, B, Grosclaude, F, Hall, JG, Hines, H, Leveziel, H, Newman, MJ, Stear, MJ, Stone, WH & Vaiman, M 1979, 'Analysis of alloantisera against bovine lymphocytes. Joint report of the 1st International Bovine Lymphocyte Antigen (BoLA) Workshop', Animal Blood Groups and Biochemical Genetics, vol. 10, no. 2, pp. 63-86. https://doi.org/10.1111/j.1365-2052.1979.tb01009.x

TY - JOUR

T1 - Analysis of alloantisera against bovine lymphocytes. Joint report of the 1st International Bovine Lymphocyte Antigen (BoLA) Workshop

AU - Spooner, R. L.

AU - Oliver, R. A.

AU - Sales, D. I.

AU - McCoubrey, C. M.

AU - Millar, P.

AU - Morgan, A. G.

AU - Amorena, B.

AU - Bailey, E.

AU - Bernoco, D.

AU - Brandon, M.

AU - Bull, R. W.

AU - Caldwell, J.

AU - Cwik, S.

AU - van Dam, R. H.

AU - Dodd, J.

AU - Gahne, B.

AU - Grosclaude, F.

AU - Hall, J. G.

AU - Hines, H.

AU - Leveziel, H.

AU - Newman, M. J.

AU - Stear, M. J.

AU - Stone, W. H.

AU - Vaiman, M.

PY - 1979/4

Y1 - 1979/4

N2 - The results and agreements of the 1st international BoLA workshop, held in Edinburgh, Scotland in August 1978, are reported. Most of these concern the results from a comparison test of 249 alloantisera to bovine lymphocytes, the antisera being contributed by 9 laboratories. These sera were compared directly in Edinburgh on a panel of lymphocytes from 130 cattle of 21 breeds. In the micro‐lymphocytotoxicity test used 75% of the sera reacted. Sixty eight of these sera were grouped into clusters according to their reaction patterns against the lymphocyte panel. Eleven of these clusters were clearly defined and were given workshop BoLA designations. In addition 22 sera were assigned to subgroups of the agreed clusters. There was no evidence that the method of production of the sera had any effect on their specificity. Although genetic data was not available, the phenotypes of the test panel of lymphocytes are consistent with the clusters detecting antigens controlled by multiple alleles at a single autosomal locus. It was agreed to name the genetic region where this putative locus is located BoLA (bovine lymphocyte antigen).

AB - The results and agreements of the 1st international BoLA workshop, held in Edinburgh, Scotland in August 1978, are reported. Most of these concern the results from a comparison test of 249 alloantisera to bovine lymphocytes, the antisera being contributed by 9 laboratories. These sera were compared directly in Edinburgh on a panel of lymphocytes from 130 cattle of 21 breeds. In the micro‐lymphocytotoxicity test used 75% of the sera reacted. Sixty eight of these sera were grouped into clusters according to their reaction patterns against the lymphocyte panel. Eleven of these clusters were clearly defined and were given workshop BoLA designations. In addition 22 sera were assigned to subgroups of the agreed clusters. There was no evidence that the method of production of the sera had any effect on their specificity. Although genetic data was not available, the phenotypes of the test panel of lymphocytes are consistent with the clusters detecting antigens controlled by multiple alleles at a single autosomal locus. It was agreed to name the genetic region where this putative locus is located BoLA (bovine lymphocyte antigen).

KW - BoLA

KW - MHS

KW - bovine lymphocyte antigen

KW - cattle

KW - comparison test

KW - major histocompatibility system

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U2 - 10.1111/j.1365-2052.1979.tb01009.x

DO - 10.1111/j.1365-2052.1979.tb01009.x

M3 - Article

C2 - 507476

AN - SCOPUS:0018673590

SN - 0003-3480

VL - 10

SP - 63

EP - 86

JO - Animal Blood Groups and Biochemical Genetics

JF - Animal Blood Groups and Biochemical Genetics

IS - 2

ER -

Analysis of alloantisera against bovine lymphocytes. Joint report of the 1st International Bovine Lymphocyte Antigen (BoLA) Workshop

Abstract

Keywords

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