Analysis of alternative splicing with microarrays

Jingyi Hui, Shivendra Kishore, Amit Khanna, Stefan Stamm

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Scopus citations


Alternative splicing is one of the most important post-transcriptional processing steps that enhances genomic information by generating multiple RNA isoforms from a single gene. Recently, microarrays have been developed that can detect changes in splice site selection. Currently, the biggest challenge for the analysis of alternative splicing with microarrays is the bioinformatics analysis of array data and their low reproducibility by RT-PCR. Despite these problems, microarrays revealed an unexpected number of expressed RNAs, showed changes of alternative splicing in diseases and indicated that a splicing factor regulates a biologically meaningful set of genes.

Original languageEnglish
Title of host publicationBioinformatics for Systems Biology
Number of pages13
ISBN (Electronic)9781597454407
StatePublished - 2009

Bibliographical note

Publisher Copyright:
© Humana Press, a part of Springer Science-Business Media, LLC 2009. All rights reserved.


  • Alternative splicing
  • Exon
  • Experimental validation
  • Microarrays
  • RNA isoforms
  • intron

ASJC Scopus subject areas

  • General Medicine


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