TY - JOUR
T1 - Analysis of circulating metabolites to differentiate Parkinson's disease and essential tremor
AU - Ostrakhovitch, Elena A.
AU - Song, Eun Suk
AU - Macedo, Jessica K.A.
AU - Gentry, Matthew S.
AU - Quintero, Jorge E.
AU - van Horne, Craig
AU - Yamasaki, Tritia R.
N1 - Publisher Copyright:
© 2021
PY - 2022/1/19
Y1 - 2022/1/19
N2 - Parkinson's disease (PD) and essential tremor (ET) are two common adult-onset tremor disorders in which prevalence increases with age. PD is a neurodegenerative condition with progressive disability. In ET, neurodegeneration is not an established etiology. We sought to determine whether an underlying metabolic pattern may differentiate ET from PD. Circulating metabolites in plasma and cerebrospinal fluid (CSF) were analyzed using gas chromatography-mass spectroscopy. There were several disrupted pathways in PD compared to ET plasma including glycolysis, tyrosine, phenylalanine, tyrosine biosynthesis, purine and glutathione metabolism. Elevated α-synuclein levels in plasma and CSF distinguished PD from ET. The perturbed metabolic state in PD was associated with imbalance in the pentose phosphate pathway, deficits in energy production, and change in NADPH, NADH and nicotinamide phosphoribosyltransferase levels. This work demonstrates significant metabolic differences in plasma and CSF of PD and ET patients.
AB - Parkinson's disease (PD) and essential tremor (ET) are two common adult-onset tremor disorders in which prevalence increases with age. PD is a neurodegenerative condition with progressive disability. In ET, neurodegeneration is not an established etiology. We sought to determine whether an underlying metabolic pattern may differentiate ET from PD. Circulating metabolites in plasma and cerebrospinal fluid (CSF) were analyzed using gas chromatography-mass spectroscopy. There were several disrupted pathways in PD compared to ET plasma including glycolysis, tyrosine, phenylalanine, tyrosine biosynthesis, purine and glutathione metabolism. Elevated α-synuclein levels in plasma and CSF distinguished PD from ET. The perturbed metabolic state in PD was associated with imbalance in the pentose phosphate pathway, deficits in energy production, and change in NADPH, NADH and nicotinamide phosphoribosyltransferase levels. This work demonstrates significant metabolic differences in plasma and CSF of PD and ET patients.
KW - Alpha-synuclein
KW - Cerebrospinal fluid
KW - Metabolomic analysis
KW - Parkinson's disease
KW - Plasma
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UR - http://www.scopus.com/inward/citedby.url?scp=85122231910&partnerID=8YFLogxK
U2 - 10.1016/j.neulet.2021.136428
DO - 10.1016/j.neulet.2021.136428
M3 - Article
C2 - 34971771
AN - SCOPUS:85122231910
SN - 0304-3940
VL - 769
JO - Neuroscience Letters
JF - Neuroscience Letters
M1 - 136428
ER -