Parkinson's disease (PD) and essential tremor (ET) are two common adult-onset tremor disorders in which prevalence increases with age. PD is a neurodegenerative condition with progressive disability. In ET, neurodegeneration is not an established etiology. We sought to determine whether an underlying metabolic pattern may differentiate ET from PD. Circulating metabolites in plasma and cerebrospinal fluid (CSF) were analyzed using gas chromatography-mass spectroscopy. There were several disrupted pathways in PD compared to ET plasma including glycolysis, tyrosine, phenylalanine, tyrosine biosynthesis, purine and glutathione metabolism. Elevated α-synuclein levels in plasma and CSF distinguished PD from ET. The perturbed metabolic state in PD was associated with imbalance in the pentose phosphate pathway, deficits in energy production, and change in NADPH, NADH and nicotinamide phosphoribosyltransferase levels. This work demonstrates significant metabolic differences in plasma and CSF of PD and ET patients.
|State||Published - Jan 19 2022|
Bibliographical noteFunding Information:
This study was supported by the University of Kentucky College of Medicine’s Brain and Epilepsy Alliance for Metabolism Research and a CCTS KL2 award under NIH UL1TR001998 (T.R.Y). The research was also supported by the National Institute of Health (NIH) grants R35 NS116824 (M.S.G.). J.K.A.M. was supported by NIH/NCI training grant T32CA165990.
The authors would like to express our deep appreciation to our patients at the University of Kentucky Neuroscience Institute for their participation in this study. We are also grateful to Dr. Ramon Sun of the Neuroscience Department for constructive comments.
- Cerebrospinal fluid
- Metabolomic analysis
- Parkinson's disease
ASJC Scopus subject areas
- Neuroscience (all)