Analysis of factors influencing the development of xerostomia during intensity-modulated radiotherapy

Ken Randall; Jason Stevens; Juan Fernando Yepes; Marcus E. Randall; Mahesh Kudrimoti; Jonathan Feddock; Jing Xi; Richard J. Kryscio; Craig S. Miller

doi:10.1016/j.oooo.2013.01.006

Analysis of factors influencing the development of xerostomia during intensity-modulated radiotherapy

Ken Randall, Jason Stevens, Juan Fernando Yepes, Marcus E. Randall, Mahesh Kudrimoti, Jonathan Feddock, Jing Xi, Richard J. Kryscio, Craig S. Miller

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Objectives: Factors influencing xerostomia during intensity-modulated radiation therapy (IMRT) were assessed. Methods: A 6-week study of 32 head and neck cancer (HNC) patients was performed. Subjects completed the Xerostomia Inventory (XI) and provided stimulated saliva (SS) at baseline, week 2 and at end of IMRT. Influence of SS flow rate (SSFR), calcium and mucin 5b (MUC5b) concentrations and radiation dose on xerostomia was determined. Results: HNC subjects experienced mean SSFR decline of 36% by visit 2 (N = 27; P = .012) and 57% by visit 3 (N = 20; P = .0004). Concentrations of calcium and MUC5b increased, but not significantly during IMRT (P > .05). Xerostomia correlated most with decreasing salivary flow rate as determined by Spearman correlations (P < .04) and linear mixed models (P < .0001). Conclusions: Although IMRT is sparing to the parotid glands, it has an early effect on SSFR and the constituents in saliva in a manner that is associated with the perception of xerostomia.

Original language	English
Pages (from-to)	772-779
Number of pages	8
Journal	Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Volume	115
Issue number	6
DOIs	https://doi.org/10.1016/j.oooo.2013.01.006
State	Published - Jun 2013

Bibliographical note

Funding Information:
This study was supported by the grants from the National Institute of Health U01 DE017793 and M01-RR02602 , the University of Kentucky General Clinical Research Core and partially supported by the Clinical Translational Science Award: UL1RR033173.

ASJC Scopus subject areas

Surgery
Oral Surgery
Pathology and Forensic Medicine
Dentistry (miscellaneous)
Radiology Nuclear Medicine and imaging

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.oooo.2013.01.006

Cite this

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title = "Analysis of factors influencing the development of xerostomia during intensity-modulated radiotherapy",

abstract = "Objectives: Factors influencing xerostomia during intensity-modulated radiation therapy (IMRT) were assessed. Methods: A 6-week study of 32 head and neck cancer (HNC) patients was performed. Subjects completed the Xerostomia Inventory (XI) and provided stimulated saliva (SS) at baseline, week 2 and at end of IMRT. Influence of SS flow rate (SSFR), calcium and mucin 5b (MUC5b) concentrations and radiation dose on xerostomia was determined. Results: HNC subjects experienced mean SSFR decline of 36% by visit 2 (N = 27; P = .012) and 57% by visit 3 (N = 20; P = .0004). Concentrations of calcium and MUC5b increased, but not significantly during IMRT (P > .05). Xerostomia correlated most with decreasing salivary flow rate as determined by Spearman correlations (P < .04) and linear mixed models (P < .0001). Conclusions: Although IMRT is sparing to the parotid glands, it has an early effect on SSFR and the constituents in saliva in a manner that is associated with the perception of xerostomia.",

author = "Ken Randall and Jason Stevens and Yepes, {Juan Fernando} and Randall, {Marcus E.} and Mahesh Kudrimoti and Jonathan Feddock and Jing Xi and Kryscio, {Richard J.} and Miller, {Craig S.}",

note = "Funding Information: This study was supported by the grants from the National Institute of Health U01 DE017793 and M01-RR02602 , the University of Kentucky General Clinical Research Core and partially supported by the Clinical Translational Science Award: UL1RR033173. ",

year = "2013",

month = jun,

doi = "10.1016/j.oooo.2013.01.006",

language = "English",

volume = "115",

pages = "772--779",

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T1 - Analysis of factors influencing the development of xerostomia during intensity-modulated radiotherapy

AU - Randall, Ken

AU - Stevens, Jason

AU - Yepes, Juan Fernando

AU - Randall, Marcus E.

AU - Kudrimoti, Mahesh

AU - Feddock, Jonathan

AU - Xi, Jing

AU - Kryscio, Richard J.

AU - Miller, Craig S.

N1 - Funding Information: This study was supported by the grants from the National Institute of Health U01 DE017793 and M01-RR02602 , the University of Kentucky General Clinical Research Core and partially supported by the Clinical Translational Science Award: UL1RR033173.

PY - 2013/6

Y1 - 2013/6

N2 - Objectives: Factors influencing xerostomia during intensity-modulated radiation therapy (IMRT) were assessed. Methods: A 6-week study of 32 head and neck cancer (HNC) patients was performed. Subjects completed the Xerostomia Inventory (XI) and provided stimulated saliva (SS) at baseline, week 2 and at end of IMRT. Influence of SS flow rate (SSFR), calcium and mucin 5b (MUC5b) concentrations and radiation dose on xerostomia was determined. Results: HNC subjects experienced mean SSFR decline of 36% by visit 2 (N = 27; P = .012) and 57% by visit 3 (N = 20; P = .0004). Concentrations of calcium and MUC5b increased, but not significantly during IMRT (P > .05). Xerostomia correlated most with decreasing salivary flow rate as determined by Spearman correlations (P < .04) and linear mixed models (P < .0001). Conclusions: Although IMRT is sparing to the parotid glands, it has an early effect on SSFR and the constituents in saliva in a manner that is associated with the perception of xerostomia.

AB - Objectives: Factors influencing xerostomia during intensity-modulated radiation therapy (IMRT) were assessed. Methods: A 6-week study of 32 head and neck cancer (HNC) patients was performed. Subjects completed the Xerostomia Inventory (XI) and provided stimulated saliva (SS) at baseline, week 2 and at end of IMRT. Influence of SS flow rate (SSFR), calcium and mucin 5b (MUC5b) concentrations and radiation dose on xerostomia was determined. Results: HNC subjects experienced mean SSFR decline of 36% by visit 2 (N = 27; P = .012) and 57% by visit 3 (N = 20; P = .0004). Concentrations of calcium and MUC5b increased, but not significantly during IMRT (P > .05). Xerostomia correlated most with decreasing salivary flow rate as determined by Spearman correlations (P < .04) and linear mixed models (P < .0001). Conclusions: Although IMRT is sparing to the parotid glands, it has an early effect on SSFR and the constituents in saliva in a manner that is associated with the perception of xerostomia.

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Analysis of factors influencing the development of xerostomia during intensity-modulated radiotherapy

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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