TY - JOUR
T1 - Angiotensin and single nephron glomerular function in the trout Salmo gairdneri
AU - Brown, J. A.
AU - Oliver, J. A.
AU - Henderson, I. W.
AU - Jackson, B. A.
PY - 1980
Y1 - 1980
N2 - Glomerular filtration rate (GFR), urine flow (UV), renal tubular transport maximum for glucose (TMG) and single nephron glomerular filtration rate (SNGFR), determined in anesthetized norepinephrine-infused trout (Salmo gairdneri), were 18.51 ± 5.78 μl.min-1.kg body wt-1, 5.31 ± 1.38 μl.min-1.kg body wt-1, 105.21 ± 46.84 μg.min-1.kg body wt-1, and 3.74 ± 1.12 nl/min, respectively, when in seawater (SW) and 140.39 ± 17.24, 76.38 ± 10.41, 626.16 ± 77.46, and 1.31 ± 0.20 in freshwater (FW). Angiotensin II infusions, to reduce UV, GFR, and TMG by 50%, had no effect on the average SNGFR of FW trout, but reduced that of SW fish to 1.42 ± 0.19 nl/min. Infusion of 20% ferrocyanide, visualized as Prussian blue (PB), identified three glomerular populations: filtering (F) with PB in glomerular vessels and tubular lumen; nonfiltering (MF) - PB in glomerular vessels only; nonperfused (MP) - no PB associated with the nephron. SW and FW kidneys contained about 40% NF tubules. In FW, 45% were F tubules compared with 5% in SW, whereas NP tubules comprised 51% of SW tubules and 13% of FW. During angiotensin II infusions the distributions were 9% F and 46% NF in FW and 6% F and 12% NF in SW trout.
AB - Glomerular filtration rate (GFR), urine flow (UV), renal tubular transport maximum for glucose (TMG) and single nephron glomerular filtration rate (SNGFR), determined in anesthetized norepinephrine-infused trout (Salmo gairdneri), were 18.51 ± 5.78 μl.min-1.kg body wt-1, 5.31 ± 1.38 μl.min-1.kg body wt-1, 105.21 ± 46.84 μg.min-1.kg body wt-1, and 3.74 ± 1.12 nl/min, respectively, when in seawater (SW) and 140.39 ± 17.24, 76.38 ± 10.41, 626.16 ± 77.46, and 1.31 ± 0.20 in freshwater (FW). Angiotensin II infusions, to reduce UV, GFR, and TMG by 50%, had no effect on the average SNGFR of FW trout, but reduced that of SW fish to 1.42 ± 0.19 nl/min. Infusion of 20% ferrocyanide, visualized as Prussian blue (PB), identified three glomerular populations: filtering (F) with PB in glomerular vessels and tubular lumen; nonfiltering (MF) - PB in glomerular vessels only; nonperfused (MP) - no PB associated with the nephron. SW and FW kidneys contained about 40% NF tubules. In FW, 45% were F tubules compared with 5% in SW, whereas NP tubules comprised 51% of SW tubules and 13% of FW. During angiotensin II infusions the distributions were 9% F and 46% NF in FW and 6% F and 12% NF in SW trout.
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U2 - 10.1152/ajpregu.1980.239.5.r509
DO - 10.1152/ajpregu.1980.239.5.r509
M3 - Article
C2 - 7001929
AN - SCOPUS:0019089532
SN - 0363-6119
VL - 8
SP - R509-R514
JO - American Journal of Physiology - Regulatory Integrative and Comparative Physiology
JF - American Journal of Physiology - Regulatory Integrative and Comparative Physiology
IS - 3
ER -