TY - JOUR
T1 - Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers
T2 - What we know and current controversies
AU - Moser, Debra K.
AU - Biddle, Martha J.
PY - 2003/12
Y1 - 2003/12
N2 - A little more than a decade ago, management of heart failure was changed forever when a number of randomized clinical trials confirmed that a class of drugs, angiotensin-converting enzyme (ACE) inhibitors, could improve survival in patients with heart failure. The recognition that blockade of one of the neurohumoral systems activated in heart failure could improve outcomes prompted widespread testing of other neurohumoral blockers, such as β-adrenergic blocking agents, aldosterone antagonists, and most recently, angiotensin II type 1 receptor blockers (ARBs) for the treatment of heart failure. This article describes what is known about the use of ACE inhibitors and ARBs in the management of heart failure and presents the current controversies surrounding the use of these agents.
AB - A little more than a decade ago, management of heart failure was changed forever when a number of randomized clinical trials confirmed that a class of drugs, angiotensin-converting enzyme (ACE) inhibitors, could improve survival in patients with heart failure. The recognition that blockade of one of the neurohumoral systems activated in heart failure could improve outcomes prompted widespread testing of other neurohumoral blockers, such as β-adrenergic blocking agents, aldosterone antagonists, and most recently, angiotensin II type 1 receptor blockers (ARBs) for the treatment of heart failure. This article describes what is known about the use of ACE inhibitors and ARBs in the management of heart failure and presents the current controversies surrounding the use of these agents.
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U2 - 10.1016/S0899-5885(02)00107-7
DO - 10.1016/S0899-5885(02)00107-7
M3 - Review article
C2 - 14717387
AN - SCOPUS:2342650036
SN - 0899-5885
VL - 15
SP - 423
EP - 437
JO - Critical Care Nursing Clinics of North America
JF - Critical Care Nursing Clinics of North America
IS - 4
ER -