Angiotensin I infusion reveals differential effects of angiotensin-converting enzyme in aortic resident cells on aneurysm formation

Hisashi Sawada; Masayoshi Kukida; Xiaofeng Chen; Deborah A. Howatt; Jessica J. Moorleghen; Anju Balakrishnan; Congqing Wu; Alan Daugherty; Hong S. Lu

doi:10.1253/circj.CJ-19-0955

Angiotensin I infusion reveals differential effects of angiotensin-converting enzyme in aortic resident cells on aneurysm formation

Hisashi Sawada, Masayoshi Kukida, Xiaofeng Chen, Deborah A. Howatt, Jessica J. Moorleghen, Anju Balakrishnan, Congqing Wu, Alan Daugherty, Hong S. Lu

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Angiotensin (Ang)I is cleaved by angiotensin-converting enzyme (ACE) to generate AngII. The purpose of this study was to determine the roles of ACE in endothelial and smooth muscle cells in aortic aneurysms. Methods and Results: AngI infusion led to thoracic and abdominal aortic aneurysms in low-density lipoprotein receptor-deficient mice, which were ablated by ACE inhibition. Endothelial or smooth muscle cell-specific ACE deletion resulted in reduction of AngI-induced thoracic, but not abdominal, aortic dilatation. Conclusions: AngI infusion causes thoracic and abdominal aortic aneurysms in mice. ACE in aortic resident cells has differential effects on AngI-induced thoracic and abdominal aortic aneurysms.

Original language	English
Pages (from-to)	825-829
Number of pages	5
Journal	Circulation Journal
Volume	84
Issue number	5
DOIs	https://doi.org/10.1253/circj.CJ-19-0955
State	Published - 2020

Bibliographical note

Funding Information:
The studies reported in this manuscript were supported by the National Heart, Lung, and Blood Institute (NHLBI; HL133723, HL139748). H.S. is supported by an American Heart Association postdoctoral fellowship (18POST33990468). C.W. is a K99 awardee of the NHLBI (K99HL145117).

Publisher Copyright:
© 2020 Japanese Circulation Society. All rights reserved.

Keywords

Angiotensin
Angiotensin-converting enzyme
Aortic aneurysm
Endothelial cells
Smooth muscle cells

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

Access to Document

10.1253/circj.CJ-19-0955

Cite this

@article{3ffa900a516a48ca875506fbd239393d,

title = "Angiotensin I infusion reveals differential effects of angiotensin-converting enzyme in aortic resident cells on aneurysm formation",

abstract = "Background: Angiotensin (Ang)I is cleaved by angiotensin-converting enzyme (ACE) to generate AngII. The purpose of this study was to determine the roles of ACE in endothelial and smooth muscle cells in aortic aneurysms. Methods and Results: AngI infusion led to thoracic and abdominal aortic aneurysms in low-density lipoprotein receptor-deficient mice, which were ablated by ACE inhibition. Endothelial or smooth muscle cell-specific ACE deletion resulted in reduction of AngI-induced thoracic, but not abdominal, aortic dilatation. Conclusions: AngI infusion causes thoracic and abdominal aortic aneurysms in mice. ACE in aortic resident cells has differential effects on AngI-induced thoracic and abdominal aortic aneurysms.",

keywords = "Angiotensin, Angiotensin-converting enzyme, Aortic aneurysm, Endothelial cells, Smooth muscle cells",

author = "Hisashi Sawada and Masayoshi Kukida and Xiaofeng Chen and Howatt, {Deborah A.} and Moorleghen, {Jessica J.} and Anju Balakrishnan and Congqing Wu and Alan Daugherty and Lu, {Hong S.}",

note = "Funding Information: The studies reported in this manuscript were supported by the National Heart, Lung, and Blood Institute (NHLBI; HL133723, HL139748). H.S. is supported by an American Heart Association postdoctoral fellowship (18POST33990468). C.W. is a K99 awardee of the NHLBI (K99HL145117). Publisher Copyright: {\textcopyright} 2020 Japanese Circulation Society. All rights reserved.",

year = "2020",

doi = "10.1253/circj.CJ-19-0955",

language = "English",

volume = "84",

pages = "825--829",

number = "5",

}

TY - JOUR

T1 - Angiotensin I infusion reveals differential effects of angiotensin-converting enzyme in aortic resident cells on aneurysm formation

AU - Sawada, Hisashi

AU - Kukida, Masayoshi

AU - Chen, Xiaofeng

AU - Howatt, Deborah A.

AU - Moorleghen, Jessica J.

AU - Balakrishnan, Anju

AU - Wu, Congqing

AU - Daugherty, Alan

AU - Lu, Hong S.

N1 - Funding Information: The studies reported in this manuscript were supported by the National Heart, Lung, and Blood Institute (NHLBI; HL133723, HL139748). H.S. is supported by an American Heart Association postdoctoral fellowship (18POST33990468). C.W. is a K99 awardee of the NHLBI (K99HL145117). Publisher Copyright: © 2020 Japanese Circulation Society. All rights reserved.

PY - 2020

Y1 - 2020

N2 - Background: Angiotensin (Ang)I is cleaved by angiotensin-converting enzyme (ACE) to generate AngII. The purpose of this study was to determine the roles of ACE in endothelial and smooth muscle cells in aortic aneurysms. Methods and Results: AngI infusion led to thoracic and abdominal aortic aneurysms in low-density lipoprotein receptor-deficient mice, which were ablated by ACE inhibition. Endothelial or smooth muscle cell-specific ACE deletion resulted in reduction of AngI-induced thoracic, but not abdominal, aortic dilatation. Conclusions: AngI infusion causes thoracic and abdominal aortic aneurysms in mice. ACE in aortic resident cells has differential effects on AngI-induced thoracic and abdominal aortic aneurysms.

AB - Background: Angiotensin (Ang)I is cleaved by angiotensin-converting enzyme (ACE) to generate AngII. The purpose of this study was to determine the roles of ACE in endothelial and smooth muscle cells in aortic aneurysms. Methods and Results: AngI infusion led to thoracic and abdominal aortic aneurysms in low-density lipoprotein receptor-deficient mice, which were ablated by ACE inhibition. Endothelial or smooth muscle cell-specific ACE deletion resulted in reduction of AngI-induced thoracic, but not abdominal, aortic dilatation. Conclusions: AngI infusion causes thoracic and abdominal aortic aneurysms in mice. ACE in aortic resident cells has differential effects on AngI-induced thoracic and abdominal aortic aneurysms.

KW - Angiotensin

KW - Angiotensin-converting enzyme

KW - Aortic aneurysm

KW - Endothelial cells

KW - Smooth muscle cells

UR - http://www.scopus.com/inward/record.url?scp=85083919767&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85083919767&partnerID=8YFLogxK

U2 - 10.1253/circj.CJ-19-0955

DO - 10.1253/circj.CJ-19-0955

M3 - Article

C2 - 32238693

AN - SCOPUS:85083919767

VL - 84

SP - 825

EP - 829

IS - 5

ER -

Angiotensin I infusion reveals differential effects of angiotensin-converting enzyme in aortic resident cells on aneurysm formation

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this