Abstract
Background: Angiotensin (Ang)I is cleaved by angiotensin-converting enzyme (ACE) to generate AngII. The purpose of this study was to determine the roles of ACE in endothelial and smooth muscle cells in aortic aneurysms. Methods and Results: AngI infusion led to thoracic and abdominal aortic aneurysms in low-density lipoprotein receptor-deficient mice, which were ablated by ACE inhibition. Endothelial or smooth muscle cell-specific ACE deletion resulted in reduction of AngI-induced thoracic, but not abdominal, aortic dilatation. Conclusions: AngI infusion causes thoracic and abdominal aortic aneurysms in mice. ACE in aortic resident cells has differential effects on AngI-induced thoracic and abdominal aortic aneurysms.
| Original language | English |
|---|---|
| Pages (from-to) | 825-829 |
| Number of pages | 5 |
| Journal | Circulation Journal |
| Volume | 84 |
| Issue number | 5 |
| DOIs | |
| State | Published - 2020 |
Bibliographical note
Publisher Copyright:© 2020 Japanese Circulation Society. All rights reserved.
Funding
The studies reported in this manuscript were supported by the National Heart, Lung, and Blood Institute (NHLBI; HL133723, HL139748). H.S. is supported by an American Heart Association postdoctoral fellowship (18POST33990468). C.W. is a K99 awardee of the NHLBI (K99HL145117).
| Funders | Funder number |
|---|---|
| National Heart, Lung, and Blood Institute (NHLBI) | HL133723, K99HL145117, HL139748 |
| American Heart Association | 18POST33990468 |
Keywords
- Angiotensin
- Angiotensin-converting enzyme
- Aortic aneurysm
- Endothelial cells
- Smooth muscle cells
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine