Angiotensin II-induced aortic aneurysms in mice

Hong Lu, Deborah A. Howatt, Anju Balakrishnan, Jessica J. Moorleghen, Debra L. Rateri, Lisa A. Cassis, Alan Daugherty

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Angiotensin II (AngII) infusion into mice induces both abdominal and thoracic aortic aneurysms. Continuous delivery of AngII is achieved by subcutaneous implantation of osmotic pumps. The accumulated experience of many laboratories has provided templates for standardizing procedures to enhance reproducibility of data in the quantification and characterization of AngII-induced aortic aneurysms. This chapter provides suggestions for standard protocols, experimental designs, execution, and data interpretation. It includes discussion of the confounding issues in quantifying compositional characteristics of AngII-induced aortic aneurysms.

Original languageEnglish
Title of host publicationMouse Models of Vascular Diseases
Pages197-210
Number of pages14
ISBN (Electronic)9784431558132
DOIs
StatePublished - Jan 1 2016

Keywords

  • Angiotensin II
  • Aortic aneurysms
  • Infusion
  • Mouse

ASJC Scopus subject areas

  • Medicine (all)
  • Agricultural and Biological Sciences (all)

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