Angiotensin II-induced aortic aneurysms in mice

Hong Lu; Deborah A. Howatt; Anju Balakrishnan; Jessica J. Moorleghen; Debra L. Rateri; Lisa A. Cassis; Alan Daugherty

doi:10.1007/978-4-431-55813-2_9

Angiotensin II-induced aortic aneurysms in mice

Hong Lu, Deborah A. Howatt, Anju Balakrishnan, Jessica J. Moorleghen, Debra L. Rateri, Lisa A. Cassis, Alan Daugherty

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Angiotensin II (AngII) infusion into mice induces both abdominal and thoracic aortic aneurysms. Continuous delivery of AngII is achieved by subcutaneous implantation of osmotic pumps. The accumulated experience of many laboratories has provided templates for standardizing procedures to enhance reproducibility of data in the quantification and characterization of AngII-induced aortic aneurysms. This chapter provides suggestions for standard protocols, experimental designs, execution, and data interpretation. It includes discussion of the confounding issues in quantifying compositional characteristics of AngII-induced aortic aneurysms.

Original language	English
Title of host publication	Mouse Models of Vascular Diseases
Pages	197-210
Number of pages	14
ISBN (Electronic)	9784431558132
DOIs	https://doi.org/10.1007/978-4-431-55813-2_9
State	Published - Jan 1 2016

Bibliographical note

Publisher Copyright:
© Springer Japan 2016.

Keywords

Angiotensin II
Aortic aneurysms
Infusion
Mouse

ASJC Scopus subject areas

General Medicine
General Agricultural and Biological Sciences

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10.1007/978-4-431-55813-2_9

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abstract = "Angiotensin II (AngII) infusion into mice induces both abdominal and thoracic aortic aneurysms. Continuous delivery of AngII is achieved by subcutaneous implantation of osmotic pumps. The accumulated experience of many laboratories has provided templates for standardizing procedures to enhance reproducibility of data in the quantification and characterization of AngII-induced aortic aneurysms. This chapter provides suggestions for standard protocols, experimental designs, execution, and data interpretation. It includes discussion of the confounding issues in quantifying compositional characteristics of AngII-induced aortic aneurysms.",

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AU - Cassis, Lisa A.

AU - Daugherty, Alan

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AB - Angiotensin II (AngII) infusion into mice induces both abdominal and thoracic aortic aneurysms. Continuous delivery of AngII is achieved by subcutaneous implantation of osmotic pumps. The accumulated experience of many laboratories has provided templates for standardizing procedures to enhance reproducibility of data in the quantification and characterization of AngII-induced aortic aneurysms. This chapter provides suggestions for standard protocols, experimental designs, execution, and data interpretation. It includes discussion of the confounding issues in quantifying compositional characteristics of AngII-induced aortic aneurysms.

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KW - Aortic aneurysms

KW - Infusion

KW - Mouse

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ER -

Angiotensin II-induced aortic aneurysms in mice

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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