Animal models for oral transmission of Listeria monocytogenes

Research output: Contribution to journalShort surveypeer-review

26 Scopus citations

Abstract

Listeria monocytogenes has been recognized as a food borne pathogen in humans since the 1980s, but we still understand very little about oral transmission of L. monocytogenes or the host factors that determine susceptibility to gastrointestinal infection, due to the lack of an appropriate small animal model of oral listeriosis. Early feeding trials suggested that many animals were highly resistant to oral infection, and the more reproducible intravenous or intraperitoneal routes of inoculation soon came to be favored. There are a fair number of previously published studies using an oral infection route, but the work varies widely in terms of bacterial strain choice, the methods used for oral transmission, and various manipulations used to enhance infectivity. This mini review summarizes the published literature using oral routes of L. monocytogenes infection and highlights recent technological advances that make oral infection a more attractive model system.

Original languageEnglish
Article numberArticle 15
JournalFrontiers in Cellular and Infection Microbiology
Volume5
Issue numberFEB
DOIs
StatePublished - 2014

Keywords

  • Food borne
  • Guinea pig
  • Intracellular pathogen
  • Intragastric
  • Listeriosis
  • Mouse

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases

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