Animal Models of Vascular Cognitive Impairment and Dementia (VCID)

Jennifer Gooch, Donna M. Wilcock

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations

Abstract

Vascular cognitive impairment and dementia (VCID) is the most common etiology of dementia in the elderly. Both, vascular and Alzheimer’s disease, pathologies work synergistically to create neurodegeneration and cognitive impairments. The main causes of VCID include hemorrhage/microbleed (i.e., hyperhomocysteinemia), cerebral small vessel disease, multi-infarct dementia, severe hypoperfusion (i.e., bilateral common carotid artery stenosis), strategic infarct, angiopathy (i.e., cerebral angiopathy), and hereditary vasculopathy (i.e., cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy). In this review, we will discuss the experimental animal models that have been developed to study these pathologies. We will discuss the limitations and strengths of these models and the important research findings that have advanced the field through the use of the models.

Original languageEnglish
Pages (from-to)233-239
Number of pages7
JournalCellular and Molecular Neurobiology
Volume36
Issue number2
DOIs
StatePublished - Mar 1 2016

Bibliographical note

Publisher Copyright:
© 2016, Springer Science+Business Media New York.

Keywords

  • Alzheimer’s disease
  • Animal model
  • Neuropathology
  • Neurovasculature
  • Vascular cognitive impairment and dementia (VCID)

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology

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