Abstract
Background: To evaluate if treating maternal periodontal disease, a pro-inflammatory condition, during pregnancy (intervention) compared to after pregnancy (control) reduces the likelihood of offspring screening positive for autism spectrum disorder (ASD). Methods: In a follow-up study to the MOTOR randomized trial, we compared rates of positive screens on the Modified Checklist for Autism in Toddlers (M-CHAT) among n = 306 two-year-old toddlers and correlated findings to maternal and cord blood pro-inflammatory interleukin-6 (IL-6). Results: Toddlers in the intervention group had decreased risk of a positive M-CHAT screen (adjusted RR = 0.53, 95% CI 0.29–0.99). Toddlers screening positive compared to negative had higher mean IL-6 in cord blood (1.58 ± 1.14 vs. 1.09 ± 0.72 p = 0.001) and maternal IL-6 change from baseline (1.30 ± 0.61 vs 0.96 ± 0.62 p = 0.03). Conclusions: Treating periodontal disease during pregnancy reduced risk of a positive ASD screen. M-CHAT positivity was associated with increased IL-6 in maternal and cord blood. Clinical trial: Trial Registration numbers: Clinicaltrials.gov NCT03423836.
Original language | English |
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Pages (from-to) | 470-476 |
Number of pages | 7 |
Journal | Journal of Perinatology |
Volume | 43 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2023 |
Bibliographical note
Funding Information:We want to extend our sincerest gratitude to Dr. Steven Offenbacher, the primary investigator of the MOTOR trial. The dental, medical, and scientific communities all had a significant loss with Dr. Offenbacher’s passing. We want to acknowledge the NIH and the MOTOR and MOTORKids investigators and teams. This study was supported by the NIDCR (3U01DE014577) and the NCRR (RR00046, UL1RR025747). We acknowledge the additional grant support of the NIH K01DE027087 (PI JTM) and K23HD105929 (PI GV).
Funding Information:
We want to extend our sincerest gratitude to Dr. Steven Offenbacher, the primary investigator of the MOTOR trial. The dental, medical, and scientific communities all had a significant loss with Dr. Offenbacher’s passing. We want to acknowledge the NIH and the MOTOR and MOTORKids investigators and teams. This study was supported by the NIDCR (3U01DE014577) and the NCRR (RR00046, UL1RR025747). We acknowledge the additional grant support of the NIH K01DE027087 (PI JTM) and K23HD105929 (PI GV).
Publisher Copyright:
© 2023, The Author(s), under exclusive licence to Springer Nature America, Inc.
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Obstetrics and Gynecology