Antepartum periodontitis treatment and risk of offspring screening positive for autism spectrum disorder

Carl Bose, Gregory C. Valentine, Kamaira Philips, Kim Boggess, Kevin Moss, Silvana P. Barros, Julie Marchesan, Di Wu, Thomas M. O’Shea, Myriam Peralta-Carcelen, Ricki Goldstein, Rajam Ramamurthy, James D. Beck

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: To evaluate if treating maternal periodontal disease, a pro-inflammatory condition, during pregnancy (intervention) compared to after pregnancy (control) reduces the likelihood of offspring screening positive for autism spectrum disorder (ASD). Methods: In a follow-up study to the MOTOR randomized trial, we compared rates of positive screens on the Modified Checklist for Autism in Toddlers (M-CHAT) among n = 306 two-year-old toddlers and correlated findings to maternal and cord blood pro-inflammatory interleukin-6 (IL-6). Results: Toddlers in the intervention group had decreased risk of a positive M-CHAT screen (adjusted RR = 0.53, 95% CI 0.29–0.99). Toddlers screening positive compared to negative had higher mean IL-6 in cord blood (1.58 ± 1.14 vs. 1.09 ± 0.72 p = 0.001) and maternal IL-6 change from baseline (1.30 ± 0.61 vs 0.96 ± 0.62 p = 0.03). Conclusions: Treating periodontal disease during pregnancy reduced risk of a positive ASD screen. M-CHAT positivity was associated with increased IL-6 in maternal and cord blood. Clinical trial: Trial Registration numbers: Clinicaltrials.gov NCT03423836.

Original languageEnglish
Pages (from-to)470-476
Number of pages7
JournalJournal of Perinatology
Volume43
Issue number4
DOIs
StatePublished - Apr 2023

Bibliographical note

Publisher Copyright:
© 2023, The Author(s), under exclusive licence to Springer Nature America, Inc.

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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