TY - JOUR
T1 - Antepartum periodontitis treatment and risk of offspring screening positive for autism spectrum disorder
AU - Bose, Carl
AU - Valentine, Gregory C.
AU - Philips, Kamaira
AU - Boggess, Kim
AU - Moss, Kevin
AU - Barros, Silvana P.
AU - Marchesan, Julie
AU - Wu, Di
AU - O’Shea, Thomas M.
AU - Peralta-Carcelen, Myriam
AU - Goldstein, Ricki
AU - Ramamurthy, Rajam
AU - Beck, James D.
N1 - Publisher Copyright:
© 2023, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2023/4
Y1 - 2023/4
N2 - Background: To evaluate if treating maternal periodontal disease, a pro-inflammatory condition, during pregnancy (intervention) compared to after pregnancy (control) reduces the likelihood of offspring screening positive for autism spectrum disorder (ASD). Methods: In a follow-up study to the MOTOR randomized trial, we compared rates of positive screens on the Modified Checklist for Autism in Toddlers (M-CHAT) among n = 306 two-year-old toddlers and correlated findings to maternal and cord blood pro-inflammatory interleukin-6 (IL-6). Results: Toddlers in the intervention group had decreased risk of a positive M-CHAT screen (adjusted RR = 0.53, 95% CI 0.29–0.99). Toddlers screening positive compared to negative had higher mean IL-6 in cord blood (1.58 ± 1.14 vs. 1.09 ± 0.72 p = 0.001) and maternal IL-6 change from baseline (1.30 ± 0.61 vs 0.96 ± 0.62 p = 0.03). Conclusions: Treating periodontal disease during pregnancy reduced risk of a positive ASD screen. M-CHAT positivity was associated with increased IL-6 in maternal and cord blood. Clinical trial: Trial Registration numbers: Clinicaltrials.gov NCT03423836.
AB - Background: To evaluate if treating maternal periodontal disease, a pro-inflammatory condition, during pregnancy (intervention) compared to after pregnancy (control) reduces the likelihood of offspring screening positive for autism spectrum disorder (ASD). Methods: In a follow-up study to the MOTOR randomized trial, we compared rates of positive screens on the Modified Checklist for Autism in Toddlers (M-CHAT) among n = 306 two-year-old toddlers and correlated findings to maternal and cord blood pro-inflammatory interleukin-6 (IL-6). Results: Toddlers in the intervention group had decreased risk of a positive M-CHAT screen (adjusted RR = 0.53, 95% CI 0.29–0.99). Toddlers screening positive compared to negative had higher mean IL-6 in cord blood (1.58 ± 1.14 vs. 1.09 ± 0.72 p = 0.001) and maternal IL-6 change from baseline (1.30 ± 0.61 vs 0.96 ± 0.62 p = 0.03). Conclusions: Treating periodontal disease during pregnancy reduced risk of a positive ASD screen. M-CHAT positivity was associated with increased IL-6 in maternal and cord blood. Clinical trial: Trial Registration numbers: Clinicaltrials.gov NCT03423836.
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U2 - 10.1038/s41372-023-01610-x
DO - 10.1038/s41372-023-01610-x
M3 - Article
C2 - 36697694
AN - SCOPUS:85146851757
SN - 0743-8346
VL - 43
SP - 470
EP - 476
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 4
ER -