Antepartum periodontitis treatment and risk of offspring screening positive for autism spectrum disorder

Carl Bose; Gregory C. Valentine; Kamaira Philips; Kim Boggess; Kevin Moss; Silvana P. Barros; Julie Marchesan; Di Wu; Thomas M. O’Shea; Myriam Peralta-Carcelen; Ricki Goldstein; Rajam Ramamurthy; James D. Beck

doi:10.1038/s41372-023-01610-x

Antepartum periodontitis treatment and risk of offspring screening positive for autism spectrum disorder

Carl Bose, Gregory C. Valentine, Kamaira Philips, Kim Boggess, Kevin Moss, Silvana P. Barros, Julie Marchesan, Di Wu, Thomas M. O’Shea, Myriam Peralta-Carcelen, Ricki Goldstein, Rajam Ramamurthy, James D. Beck

Pediatrics

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Background: To evaluate if treating maternal periodontal disease, a pro-inflammatory condition, during pregnancy (intervention) compared to after pregnancy (control) reduces the likelihood of offspring screening positive for autism spectrum disorder (ASD). Methods: In a follow-up study to the MOTOR randomized trial, we compared rates of positive screens on the Modified Checklist for Autism in Toddlers (M-CHAT) among n = 306 two-year-old toddlers and correlated findings to maternal and cord blood pro-inflammatory interleukin-6 (IL-6). Results: Toddlers in the intervention group had decreased risk of a positive M-CHAT screen (adjusted RR = 0.53, 95% CI 0.29–0.99). Toddlers screening positive compared to negative had higher mean IL-6 in cord blood (1.58 ± 1.14 vs. 1.09 ± 0.72 p = 0.001) and maternal IL-6 change from baseline (1.30 ± 0.61 vs 0.96 ± 0.62 p = 0.03). Conclusions: Treating periodontal disease during pregnancy reduced risk of a positive ASD screen. M-CHAT positivity was associated with increased IL-6 in maternal and cord blood. Clinical trial: Trial Registration numbers: Clinicaltrials.gov NCT03423836.

Original language	English
Pages (from-to)	470-476
Number of pages	7
Journal	Journal of Perinatology
Volume	43
Issue number	4
DOIs	https://doi.org/10.1038/s41372-023-01610-x
State	Published - Apr 2023

Bibliographical note

Funding Information:
We want to extend our sincerest gratitude to Dr. Steven Offenbacher, the primary investigator of the MOTOR trial. The dental, medical, and scientific communities all had a significant loss with Dr. Offenbacher’s passing. We want to acknowledge the NIH and the MOTOR and MOTORKids investigators and teams. This study was supported by the NIDCR (3U01DE014577) and the NCRR (RR00046, UL1RR025747). We acknowledge the additional grant support of the NIH K01DE027087 (PI JTM) and K23HD105929 (PI GV).

Funding Information:
We want to extend our sincerest gratitude to Dr. Steven Offenbacher, the primary investigator of the MOTOR trial. The dental, medical, and scientific communities all had a significant loss with Dr. Offenbacher’s passing. We want to acknowledge the NIH and the MOTOR and MOTORKids investigators and teams. This study was supported by the NIDCR (3U01DE014577) and the NCRR (RR00046, UL1RR025747). We acknowledge the additional grant support of the NIH K01DE027087 (PI JTM) and K23HD105929 (PI GV).

Publisher Copyright:
© 2023, The Author(s), under exclusive licence to Springer Nature America, Inc.

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology

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10.1038/s41372-023-01610-x

Cite this

Bose, C., Valentine, G. C., Philips, K., Boggess, K., Moss, K., Barros, S. P., Marchesan, J., Wu, D., O’Shea, T. M., Peralta-Carcelen, M., Goldstein, R., Ramamurthy, R., & Beck, J. D. (2023). Antepartum periodontitis treatment and risk of offspring screening positive for autism spectrum disorder. Journal of Perinatology, 43(4), 470-476. https://doi.org/10.1038/s41372-023-01610-x

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abstract = "Background: To evaluate if treating maternal periodontal disease, a pro-inflammatory condition, during pregnancy (intervention) compared to after pregnancy (control) reduces the likelihood of offspring screening positive for autism spectrum disorder (ASD). Methods: In a follow-up study to the MOTOR randomized trial, we compared rates of positive screens on the Modified Checklist for Autism in Toddlers (M-CHAT) among n = 306 two-year-old toddlers and correlated findings to maternal and cord blood pro-inflammatory interleukin-6 (IL-6). Results: Toddlers in the intervention group had decreased risk of a positive M-CHAT screen (adjusted RR = 0.53, 95% CI 0.29–0.99). Toddlers screening positive compared to negative had higher mean IL-6 in cord blood (1.58 ± 1.14 vs. 1.09 ± 0.72 p = 0.001) and maternal IL-6 change from baseline (1.30 ± 0.61 vs 0.96 ± 0.62 p = 0.03). Conclusions: Treating periodontal disease during pregnancy reduced risk of a positive ASD screen. M-CHAT positivity was associated with increased IL-6 in maternal and cord blood. Clinical trial: Trial Registration numbers: Clinicaltrials.gov NCT03423836.",

author = "Carl Bose and Valentine, {Gregory C.} and Kamaira Philips and Kim Boggess and Kevin Moss and Barros, {Silvana P.} and Julie Marchesan and Di Wu and O{\textquoteright}Shea, {Thomas M.} and Myriam Peralta-Carcelen and Ricki Goldstein and Rajam Ramamurthy and Beck, {James D.}",

note = "Funding Information: We want to extend our sincerest gratitude to Dr. Steven Offenbacher, the primary investigator of the MOTOR trial. The dental, medical, and scientific communities all had a significant loss with Dr. Offenbacher{\textquoteright}s passing. We want to acknowledge the NIH and the MOTOR and MOTORKids investigators and teams. This study was supported by the NIDCR (3U01DE014577) and the NCRR (RR00046, UL1RR025747). We acknowledge the additional grant support of the NIH K01DE027087 (PI JTM) and K23HD105929 (PI GV). Funding Information: We want to extend our sincerest gratitude to Dr. Steven Offenbacher, the primary investigator of the MOTOR trial. The dental, medical, and scientific communities all had a significant loss with Dr. Offenbacher{\textquoteright}s passing. We want to acknowledge the NIH and the MOTOR and MOTORKids investigators and teams. This study was supported by the NIDCR (3U01DE014577) and the NCRR (RR00046, UL1RR025747). We acknowledge the additional grant support of the NIH K01DE027087 (PI JTM) and K23HD105929 (PI GV). Publisher Copyright: {\textcopyright} 2023, The Author(s), under exclusive licence to Springer Nature America, Inc.",

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Bose, C, Valentine, GC, Philips, K, Boggess, K, Moss, K, Barros, SP, Marchesan, J, Wu, D, O’Shea, TM, Peralta-Carcelen, M, Goldstein, R, Ramamurthy, R & Beck, JD 2023, 'Antepartum periodontitis treatment and risk of offspring screening positive for autism spectrum disorder', Journal of Perinatology, vol. 43, no. 4, pp. 470-476. https://doi.org/10.1038/s41372-023-01610-x

TY - JOUR

T1 - Antepartum periodontitis treatment and risk of offspring screening positive for autism spectrum disorder

AU - Bose, Carl

AU - Valentine, Gregory C.

AU - Philips, Kamaira

AU - Boggess, Kim

AU - Moss, Kevin

AU - Barros, Silvana P.

AU - Marchesan, Julie

AU - Wu, Di

AU - O’Shea, Thomas M.

AU - Peralta-Carcelen, Myriam

AU - Goldstein, Ricki

AU - Ramamurthy, Rajam

AU - Beck, James D.

N1 - Funding Information: We want to extend our sincerest gratitude to Dr. Steven Offenbacher, the primary investigator of the MOTOR trial. The dental, medical, and scientific communities all had a significant loss with Dr. Offenbacher’s passing. We want to acknowledge the NIH and the MOTOR and MOTORKids investigators and teams. This study was supported by the NIDCR (3U01DE014577) and the NCRR (RR00046, UL1RR025747). We acknowledge the additional grant support of the NIH K01DE027087 (PI JTM) and K23HD105929 (PI GV). Funding Information: We want to extend our sincerest gratitude to Dr. Steven Offenbacher, the primary investigator of the MOTOR trial. The dental, medical, and scientific communities all had a significant loss with Dr. Offenbacher’s passing. We want to acknowledge the NIH and the MOTOR and MOTORKids investigators and teams. This study was supported by the NIDCR (3U01DE014577) and the NCRR (RR00046, UL1RR025747). We acknowledge the additional grant support of the NIH K01DE027087 (PI JTM) and K23HD105929 (PI GV). Publisher Copyright: © 2023, The Author(s), under exclusive licence to Springer Nature America, Inc.

PY - 2023/4

Y1 - 2023/4

N2 - Background: To evaluate if treating maternal periodontal disease, a pro-inflammatory condition, during pregnancy (intervention) compared to after pregnancy (control) reduces the likelihood of offspring screening positive for autism spectrum disorder (ASD). Methods: In a follow-up study to the MOTOR randomized trial, we compared rates of positive screens on the Modified Checklist for Autism in Toddlers (M-CHAT) among n = 306 two-year-old toddlers and correlated findings to maternal and cord blood pro-inflammatory interleukin-6 (IL-6). Results: Toddlers in the intervention group had decreased risk of a positive M-CHAT screen (adjusted RR = 0.53, 95% CI 0.29–0.99). Toddlers screening positive compared to negative had higher mean IL-6 in cord blood (1.58 ± 1.14 vs. 1.09 ± 0.72 p = 0.001) and maternal IL-6 change from baseline (1.30 ± 0.61 vs 0.96 ± 0.62 p = 0.03). Conclusions: Treating periodontal disease during pregnancy reduced risk of a positive ASD screen. M-CHAT positivity was associated with increased IL-6 in maternal and cord blood. Clinical trial: Trial Registration numbers: Clinicaltrials.gov NCT03423836.

AB - Background: To evaluate if treating maternal periodontal disease, a pro-inflammatory condition, during pregnancy (intervention) compared to after pregnancy (control) reduces the likelihood of offspring screening positive for autism spectrum disorder (ASD). Methods: In a follow-up study to the MOTOR randomized trial, we compared rates of positive screens on the Modified Checklist for Autism in Toddlers (M-CHAT) among n = 306 two-year-old toddlers and correlated findings to maternal and cord blood pro-inflammatory interleukin-6 (IL-6). Results: Toddlers in the intervention group had decreased risk of a positive M-CHAT screen (adjusted RR = 0.53, 95% CI 0.29–0.99). Toddlers screening positive compared to negative had higher mean IL-6 in cord blood (1.58 ± 1.14 vs. 1.09 ± 0.72 p = 0.001) and maternal IL-6 change from baseline (1.30 ± 0.61 vs 0.96 ± 0.62 p = 0.03). Conclusions: Treating periodontal disease during pregnancy reduced risk of a positive ASD screen. M-CHAT positivity was associated with increased IL-6 in maternal and cord blood. Clinical trial: Trial Registration numbers: Clinicaltrials.gov NCT03423836.

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Antepartum periodontitis treatment and risk of offspring screening positive for autism spectrum disorder

Abstract

Bibliographical note

ASJC Scopus subject areas

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