TY - JOUR
T1 - Anti-cancer effects of asiatic acid, a triterpene from centilla asiatica l
T2 - A review
AU - Islam, Muhammad T.
AU - Ali, Eunus S.
AU - Uddin, Shaikh J.
AU - Khan, Ishaq N.
AU - Shill, Manik C.
AU - Sousa, João M.de Castro e.
AU - de Alencar, Marcus V.O.Barros
AU - Melo-Cavalcante, Ana A.C.
AU - Mubarak, Mohammad S.
N1 - Publisher Copyright:
© 2020 Bentham Science Publishers.
PY - 2020
Y1 - 2020
N2 - Background: Centilla asiatica L is a medicinal herb that has been widely used in folk medicine to treat various diseases. Asiatic Acid (AA), a triterpene and a known component of this herb, has been shown to display important biological activities, including anti-inflammatory, antibacterial, antidiabetic and anti-hyperlipidemic, neuroprotective, anxiolytic and antidepressant, hepatoprotective, pancreas protective, and car-dio-protective. Objective: This review focuses on AA’s anti-cancer effects on the basis of published literature found in a number of databases such as PubMed and Science Direct. Emphasis has been given to the mechanisms of action of its anti-cancer effect. Methods: A literature survey was conducted using known databases such as PubMed and Science Direct using the keywords ‘Asiatic acid’, pairing with ‘cancer’, ‘tumor’, ‘anti-cancer effect’, ‘cytotoxic effect’, ‘anti-tumor activity’, ‘cell line’, ‘animal cancer’, and ‘human cancer’. Results: Findings suggest that AA exerts anti-cancer effects in several test systems through various pathways, including oxidative/antioxidant, anti-inflammatory, cytotoxicity, apoptotic cell death, necrosis, anti-angiogenesis, inhibition of proliferation and cell migration, and chemoprevention. Conclusion: AA may be an effective plant-based cancer chemotherapeutic agent and a promising lead for the development of potent anticancer drugs.
AB - Background: Centilla asiatica L is a medicinal herb that has been widely used in folk medicine to treat various diseases. Asiatic Acid (AA), a triterpene and a known component of this herb, has been shown to display important biological activities, including anti-inflammatory, antibacterial, antidiabetic and anti-hyperlipidemic, neuroprotective, anxiolytic and antidepressant, hepatoprotective, pancreas protective, and car-dio-protective. Objective: This review focuses on AA’s anti-cancer effects on the basis of published literature found in a number of databases such as PubMed and Science Direct. Emphasis has been given to the mechanisms of action of its anti-cancer effect. Methods: A literature survey was conducted using known databases such as PubMed and Science Direct using the keywords ‘Asiatic acid’, pairing with ‘cancer’, ‘tumor’, ‘anti-cancer effect’, ‘cytotoxic effect’, ‘anti-tumor activity’, ‘cell line’, ‘animal cancer’, and ‘human cancer’. Results: Findings suggest that AA exerts anti-cancer effects in several test systems through various pathways, including oxidative/antioxidant, anti-inflammatory, cytotoxicity, apoptotic cell death, necrosis, anti-angiogenesis, inhibition of proliferation and cell migration, and chemoprevention. Conclusion: AA may be an effective plant-based cancer chemotherapeutic agent and a promising lead for the development of potent anticancer drugs.
KW - Anticancer drugs
KW - Asiatic acid
KW - Cancer
KW - Centilla asiatica
KW - Chemotherapeutic agent
KW - Mechanisms of action
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U2 - 10.2174/1871520619666191211103006
DO - 10.2174/1871520619666191211103006
M3 - Article
C2 - 31823705
AN - SCOPUS:85085602323
SN - 1871-5206
VL - 20
SP - 536
EP - 547
JO - Anti-Cancer Agents in Medicinal Chemistry
JF - Anti-Cancer Agents in Medicinal Chemistry
IS - 5
ER -
