Our previous paper has reported that the aqueous extract from Rhizoma smilacis glabrae (RSG) (RSG ext) selectively inhibited the effector phase of delayed-type hypersensitivity (DTH) without suppressing humoral immune response. In the present study, a remarkable inhibitory activity was exhibited by the extract against both primary and secondary hind paw swelling of adjuvant arthritis in rats. RSG ext also significantly reduced the inflammatory edema induced by carrageenan in either naive or bilaterally adrenalectomized rats, suggesting the independence of the anti-inflammatory action on the function of pituitary-adrenal axis. The PGE2 content in the carrageenan-induced inflammatory tissue was also decreased remarkably by the extract. Furthermore, RSG ext showed a distinct inhibition on the formation of cotton-induced granuloma formation. However, as compared with a steroidal agent, prednisolone, the extract did not affect the vitamin C content in adrenal gland as well as the weights of some organs. These results suggest that RSG ext may act as a therapeutic agent of immunoinflammatory diseases through a selective suppression on the cellular immune response involved in inflammations as well as through a direct antiinflammatory mechanism including inhibiting PGE2.
|Number of pages||6|
|State||Published - Oct 1997|
Bibliographical noteFunding Information:
This work was supported by Trans-Century Training Program Foundation for the Talents from State Education Commission of China. We also thank Ms Jing Yan and Ms. Jun Liu for their technical assistance.
Copyright 2017 Elsevier B.V., All rights reserved.
- Adjuvant arthritis
- Anti-inflammatory activity
- Rhizoma smilacis glabrae
ASJC Scopus subject areas