TY - JOUR
T1 - Anti-inflammatory doses of ibuprofen
T2 - Effect on neutrophils and exercise-induced muscle injury
AU - Pizza, Francis X.
AU - Cavender, D.
AU - Stockard, A.
AU - Baylies, H.
AU - Beighle, A.
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 1999
Y1 - 1999
N2 - The purpose of the study was to determine the effect of anti-inflammatory doses of ibuprofen on neutrophils, neutrophil O2-· production, and markers of muscle injury. Males (n = 10) performed 2 bouts of one-arm eccentric exercise on opposite arms separated by three weeks. Subjects received 2400 mg·d-1 of ibuprofen or a placebo 5 d before exercise and during 10 d of recovery. Measurements were made before the treatments, pre-exercise, at 4 h, and at 1, 2, 3, 4 and 10 d post-exercise. Circulating neutrophil counts were similar between the treatments at the sampling points. Neutrophil counts were higher (p < 0.05) for ibuprofen and were elevated (p < 0.05) at 4 h post-exercise relative to pre-exercise in both treatments. Stimulated neutrophil O2-· production was lower for ibuprofen relative to placebo at pre-exercise and was increased (p < 0.05) at 4 h and 4 d of both treatments. CK activity at 3 d post-exercise was lower (p < 0.05) for ibuprofen relative to placebo. Isometric strength, soreness, tenderness, and arm angles were similar between the treatments. In conclusion, anti-inflammatory doses of ibuprofen reduced CK activity but not the neutrophil response or other indirect markers of muscle injury during recovery from eccentric arm exercise.
AB - The purpose of the study was to determine the effect of anti-inflammatory doses of ibuprofen on neutrophils, neutrophil O2-· production, and markers of muscle injury. Males (n = 10) performed 2 bouts of one-arm eccentric exercise on opposite arms separated by three weeks. Subjects received 2400 mg·d-1 of ibuprofen or a placebo 5 d before exercise and during 10 d of recovery. Measurements were made before the treatments, pre-exercise, at 4 h, and at 1, 2, 3, 4 and 10 d post-exercise. Circulating neutrophil counts were similar between the treatments at the sampling points. Neutrophil counts were higher (p < 0.05) for ibuprofen and were elevated (p < 0.05) at 4 h post-exercise relative to pre-exercise in both treatments. Stimulated neutrophil O2-· production was lower for ibuprofen relative to placebo at pre-exercise and was increased (p < 0.05) at 4 h and 4 d of both treatments. CK activity at 3 d post-exercise was lower (p < 0.05) for ibuprofen relative to placebo. Isometric strength, soreness, tenderness, and arm angles were similar between the treatments. In conclusion, anti-inflammatory doses of ibuprofen reduced CK activity but not the neutrophil response or other indirect markers of muscle injury during recovery from eccentric arm exercise.
KW - Creatine kinase
KW - Muscle damage
KW - Muscle soreness
KW - Superoxide anion
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U2 - 10.1055/s-2007-971100
DO - 10.1055/s-2007-971100
M3 - Article
C2 - 10190769
AN - SCOPUS:0033035385
SN - 0172-4622
VL - 20
SP - 98
EP - 102
JO - International Journal of Sports Medicine
JF - International Journal of Sports Medicine
IS - 2
ER -