Anti-inflammatory doses of ibuprofen: Effect on neutrophils and exercise-induced muscle injury

Francis X. Pizza, D. Cavender, A. Stockard, H. Baylies, A. Beighle

Research output: Contribution to journalArticlepeer-review

63 Scopus citations


The purpose of the study was to determine the effect of anti-inflammatory doses of ibuprofen on neutrophils, neutrophil O2-· production, and markers of muscle injury. Males (n = 10) performed 2 bouts of one-arm eccentric exercise on opposite arms separated by three weeks. Subjects received 2400 mg·d-1 of ibuprofen or a placebo 5 d before exercise and during 10 d of recovery. Measurements were made before the treatments, pre-exercise, at 4 h, and at 1, 2, 3, 4 and 10 d post-exercise. Circulating neutrophil counts were similar between the treatments at the sampling points. Neutrophil counts were higher (p < 0.05) for ibuprofen and were elevated (p < 0.05) at 4 h post-exercise relative to pre-exercise in both treatments. Stimulated neutrophil O2-· production was lower for ibuprofen relative to placebo at pre-exercise and was increased (p < 0.05) at 4 h and 4 d of both treatments. CK activity at 3 d post-exercise was lower (p < 0.05) for ibuprofen relative to placebo. Isometric strength, soreness, tenderness, and arm angles were similar between the treatments. In conclusion, anti-inflammatory doses of ibuprofen reduced CK activity but not the neutrophil response or other indirect markers of muscle injury during recovery from eccentric arm exercise.

Original languageEnglish
Pages (from-to)98-102
Number of pages5
JournalInternational Journal of Sports Medicine
Issue number2
StatePublished - 1999


  • Creatine kinase
  • Muscle damage
  • Muscle soreness
  • Superoxide anion

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation


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