Anti-Proliferative Naphthalene Glucoside from Aerial Part of Neanotis wightiana

Niranjan Das; Prashanta Kumar Deb; Eunus S. Ali; Manash C. Das; Biswatrish Sarkar; Siddhartha Kumar Mishra

doi:10.1007/s10600-022-03591-3

Anti-Proliferative Naphthalene Glucoside from Aerial Part of Neanotis wightiana

Niranjan Das, Prashanta Kumar Deb, Eunus S. Ali, Manash C. Das, Biswatrish Sarkar, Siddhartha Kumar Mishra

Research output: Contribution to journal › Article › peer-review

Abstract

A new bioactive naphthalene glucoside, named neanoside C (1), was isolated from the aerial part of Neanotis wightiana. The structure of neanoside C (1) was elucidated as 1,4-dihydroxy-2-(6′-Omethylglucopyranosyloxymethyl)-naphthalene-3-vinyloxyglucopyranoside by interpretation of the spectroscopic data, including 2D NMR and chemical studies. Neanoside C (1) was further subjected to screening for anticancer potential using MTT based cytotoxicity assay, LDH leakage assay, and estimation of intracellular ROS production in two human breast cancer cell line. The compound exhibited promising anti-proliferative and cytotoxic effect against MCF-7 and MDA-MB-231 cell lines with an IC₅₀ value of 22.77 nM and 35.71 nM, respectively. Neanoside C (1) also exhibited concentration-dependent intracellular LDH leakage and ROS production.

Original language	English
Pages (from-to)	21-26
Number of pages	6
Journal	Chemistry of Natural Compounds
Volume	58
Issue number	1
DOIs	https://doi.org/10.1007/s10600-022-03591-3
State	Published - Jan 2022

Bibliographical note

Publisher Copyright:
© 2022, Springer Science+Business Media, LLC, part of Springer Nature.

Keywords

Neanotis wightiana
anti-proliferative
cytotoxic
naphthalene glucoside

ASJC Scopus subject areas

General Chemistry
General Biochemistry, Genetics and Molecular Biology
Plant Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10600-022-03591-3

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title = "Anti-Proliferative Naphthalene Glucoside from Aerial Part of Neanotis wightiana",

abstract = "A new bioactive naphthalene glucoside, named neanoside C (1), was isolated from the aerial part of Neanotis wightiana. The structure of neanoside C (1) was elucidated as 1,4-dihydroxy-2-(6′-Omethylglucopyranosyloxymethyl)-naphthalene-3-vinyloxyglucopyranoside by interpretation of the spectroscopic data, including 2D NMR and chemical studies. Neanoside C (1) was further subjected to screening for anticancer potential using MTT based cytotoxicity assay, LDH leakage assay, and estimation of intracellular ROS production in two human breast cancer cell line. The compound exhibited promising anti-proliferative and cytotoxic effect against MCF-7 and MDA-MB-231 cell lines with an IC50 value of 22.77 nM and 35.71 nM, respectively. Neanoside C (1) also exhibited concentration-dependent intracellular LDH leakage and ROS production.",

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AU - Das, Niranjan

AU - Deb, Prashanta Kumar

AU - Ali, Eunus S.

AU - Das, Manash C.

AU - Sarkar, Biswatrish

AU - Mishra, Siddhartha Kumar

PY - 2022/1

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N2 - A new bioactive naphthalene glucoside, named neanoside C (1), was isolated from the aerial part of Neanotis wightiana. The structure of neanoside C (1) was elucidated as 1,4-dihydroxy-2-(6′-Omethylglucopyranosyloxymethyl)-naphthalene-3-vinyloxyglucopyranoside by interpretation of the spectroscopic data, including 2D NMR and chemical studies. Neanoside C (1) was further subjected to screening for anticancer potential using MTT based cytotoxicity assay, LDH leakage assay, and estimation of intracellular ROS production in two human breast cancer cell line. The compound exhibited promising anti-proliferative and cytotoxic effect against MCF-7 and MDA-MB-231 cell lines with an IC50 value of 22.77 nM and 35.71 nM, respectively. Neanoside C (1) also exhibited concentration-dependent intracellular LDH leakage and ROS production.

AB - A new bioactive naphthalene glucoside, named neanoside C (1), was isolated from the aerial part of Neanotis wightiana. The structure of neanoside C (1) was elucidated as 1,4-dihydroxy-2-(6′-Omethylglucopyranosyloxymethyl)-naphthalene-3-vinyloxyglucopyranoside by interpretation of the spectroscopic data, including 2D NMR and chemical studies. Neanoside C (1) was further subjected to screening for anticancer potential using MTT based cytotoxicity assay, LDH leakage assay, and estimation of intracellular ROS production in two human breast cancer cell line. The compound exhibited promising anti-proliferative and cytotoxic effect against MCF-7 and MDA-MB-231 cell lines with an IC50 value of 22.77 nM and 35.71 nM, respectively. Neanoside C (1) also exhibited concentration-dependent intracellular LDH leakage and ROS production.

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KW - anti-proliferative

KW - cytotoxic

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Anti-Proliferative Naphthalene Glucoside from Aerial Part of Neanotis wightiana

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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