Anti-Proliferative Naphthalene Glucoside from Aerial Part of Neanotis wightiana

Niranjan Das, Prashanta Kumar Deb, Eunus S. Ali, Manash C. Das, Biswatrish Sarkar, Siddhartha Kumar Mishra

Research output: Contribution to journalArticlepeer-review


A new bioactive naphthalene glucoside, named neanoside C (1), was isolated from the aerial part of Neanotis wightiana. The structure of neanoside C (1) was elucidated as 1,4-dihydroxy-2-(6′-Omethylglucopyranosyloxymethyl)-naphthalene-3-vinyloxyglucopyranoside by interpretation of the spectroscopic data, including 2D NMR and chemical studies. Neanoside C (1) was further subjected to screening for anticancer potential using MTT based cytotoxicity assay, LDH leakage assay, and estimation of intracellular ROS production in two human breast cancer cell line. The compound exhibited promising anti-proliferative and cytotoxic effect against MCF-7 and MDA-MB-231 cell lines with an IC50 value of 22.77 nM and 35.71 nM, respectively. Neanoside C (1) also exhibited concentration-dependent intracellular LDH leakage and ROS production.

Original languageEnglish
Pages (from-to)21-26
Number of pages6
JournalChemistry of Natural Compounds
Issue number1
StatePublished - Jan 2022

Bibliographical note

Publisher Copyright:
© 2022, Springer Science+Business Media, LLC, part of Springer Nature.


  • Neanotis wightiana
  • anti-proliferative
  • cytotoxic
  • naphthalene glucoside

ASJC Scopus subject areas

  • General Chemistry
  • General Biochemistry, Genetics and Molecular Biology
  • Plant Science


Dive into the research topics of 'Anti-Proliferative Naphthalene Glucoside from Aerial Part of Neanotis wightiana'. Together they form a unique fingerprint.

Cite this