Antibiotic stability in an implantable pump

Clayton R. Perry, Lisa L. Ellington, Annette Becker, Mark K. Vossen, Robert E. Burdge, Richard N. Greenberg

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


We measured the stability of vancomycin, amikacin, netilmicin, tobramycin, gentamicin, clindamycin, and aztreonam in an implantable drug pump. Two pumps were filled with the antibiotic being tested and were incubated at 37° for 3 weeks. Samples were taken daily. At 3 weeks the pumps were disassembled and examined microscopically for signs of deterioration. If the pumps were intact, bioassays were used to quantitate the biologic activity of each daily antibiotic sample. Vancomycin degraded the pump. Amikacin, netilmicin, tobramycin, gentamicin, clindamycin, and aztreonam had no effect on the pump and maintained their biologic activity over the 3‐week period.

Original languageEnglish
Pages (from-to)494-498
Number of pages5
JournalJournal of Orthopaedic Research
Issue number4
StatePublished - 1986


  • Antibiotics
  • Local administration
  • Osteomyelitis
  • Pump
  • Stability

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine


Dive into the research topics of 'Antibiotic stability in an implantable pump'. Together they form a unique fingerprint.

Cite this