TY - JOUR
T1 - Antibiotic stability in an implantable pump
AU - Perry, Clayton R.
AU - Ellington, Lisa L.
AU - Becker, Annette
AU - Vossen, Mark K.
AU - Burdge, Robert E.
AU - Greenberg, Richard N.
PY - 1986
Y1 - 1986
N2 - We measured the stability of vancomycin, amikacin, netilmicin, tobramycin, gentamicin, clindamycin, and aztreonam in an implantable drug pump. Two pumps were filled with the antibiotic being tested and were incubated at 37° for 3 weeks. Samples were taken daily. At 3 weeks the pumps were disassembled and examined microscopically for signs of deterioration. If the pumps were intact, bioassays were used to quantitate the biologic activity of each daily antibiotic sample. Vancomycin degraded the pump. Amikacin, netilmicin, tobramycin, gentamicin, clindamycin, and aztreonam had no effect on the pump and maintained their biologic activity over the 3‐week period.
AB - We measured the stability of vancomycin, amikacin, netilmicin, tobramycin, gentamicin, clindamycin, and aztreonam in an implantable drug pump. Two pumps were filled with the antibiotic being tested and were incubated at 37° for 3 weeks. Samples were taken daily. At 3 weeks the pumps were disassembled and examined microscopically for signs of deterioration. If the pumps were intact, bioassays were used to quantitate the biologic activity of each daily antibiotic sample. Vancomycin degraded the pump. Amikacin, netilmicin, tobramycin, gentamicin, clindamycin, and aztreonam had no effect on the pump and maintained their biologic activity over the 3‐week period.
KW - Antibiotics
KW - Local administration
KW - Osteomyelitis
KW - Pump
KW - Stability
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U2 - 10.1002/jor.1100040413
DO - 10.1002/jor.1100040413
M3 - Article
C2 - 3783303
AN - SCOPUS:0022862127
SN - 0736-0266
VL - 4
SP - 494
EP - 498
JO - Journal of Orthopaedic Research
JF - Journal of Orthopaedic Research
IS - 4
ER -