TY - JOUR
T1 - Antibodies to a novel leptospiral protein, LruC, in the eye fluids and sera of horses with Leptospira-associated uveitis
AU - Verma, Ashutosh
AU - Matsunaga, James
AU - Artiushin, Sergey
AU - Pinne, Marija
AU - Houwers, Dirk J.
AU - Haake, David A.
AU - Stevenson, Brian
AU - Timoney, John F.
PY - 2012/3
Y1 - 2012/3
N2 - Screening of an expression library of Leptospira interrogans with eye fluids from uveitic horses resulted in identification of a novel protein, LruC. LruC is located in the inner leaflet of the leptospiral outer membrane, and an lruC gene was detected in all tested pathogenic L. interrogans strains. LruC-specific antibody levels were significantly higher in eye fluids and sera of uveitic horses than healthy horses. These findings suggest that LruC may play a role in equine leptospiral uveitis.
AB - Screening of an expression library of Leptospira interrogans with eye fluids from uveitic horses resulted in identification of a novel protein, LruC. LruC is located in the inner leaflet of the leptospiral outer membrane, and an lruC gene was detected in all tested pathogenic L. interrogans strains. LruC-specific antibody levels were significantly higher in eye fluids and sera of uveitic horses than healthy horses. These findings suggest that LruC may play a role in equine leptospiral uveitis.
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U2 - 10.1128/CVI.05524-11
DO - 10.1128/CVI.05524-11
M3 - Article
C2 - 22237897
AN - SCOPUS:84857938819
SN - 1556-6811
VL - 19
SP - 452
EP - 456
JO - Clinical and Vaccine Immunology
JF - Clinical and Vaccine Immunology
IS - 3
ER -