Anticholinergic agents do not block light-induced circadian phase shifts

James R. Pauly; Nelson D. Horseman

doi:10.1016/0006-8993(85)90373-7

Anticholinergic agents do not block light-induced circadian phase shifts

James R. Pauly, Nelson D. Horseman

Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Depletion of brain acetylcholine (ACh) stores by central infusions of hemicholinium-3 (HC-3) did not prevent the circadian phase-shifting effects of subsequent light pulses in rats. Animals treated with atropine likewise had normal responses to light pulses. Neither delay nor advance shifts were prevented. These data do not support the view that ACh is the primary mediator of photoentrainment in the rat. The previously reported effects of carbachol injections may be non-specific.

Original language	English
Pages (from-to)	163-167
Number of pages	5
Journal	Brain Research
Volume	348
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(85)90373-7
State	Published - Nov 25 1985

Bibliographical note

Funding Information:
Supported by NSF PCM8402368. We thank Dr. Elliot Stein and Mr. Edward LeMahieu for technical assistance.

Funding

Supported by NSF PCM8402368. We thank Dr. Elliot Stein and Mr. Edward LeMahieu for technical assistance.

Funders	Funder number
National Science Foundation Arctic Social Science Program	PCM8402368
National Science Foundation Arctic Social Science Program

Keywords

acetylcholine
circadian rhythm
phase shift
suprachiasmatic nucleus

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

Access to Document

10.1016/0006-8993(85)90373-7

Cite this

@article{50c648a166ca4ed09ea6342244b601ad,

title = "Anticholinergic agents do not block light-induced circadian phase shifts",

abstract = "Depletion of brain acetylcholine (ACh) stores by central infusions of hemicholinium-3 (HC-3) did not prevent the circadian phase-shifting effects of subsequent light pulses in rats. Animals treated with atropine likewise had normal responses to light pulses. Neither delay nor advance shifts were prevented. These data do not support the view that ACh is the primary mediator of photoentrainment in the rat. The previously reported effects of carbachol injections may be non-specific.",

keywords = "acetylcholine, circadian rhythm, phase shift, suprachiasmatic nucleus",

author = "Pauly, {James R.} and Horseman, {Nelson D.}",

note = "Funding Information: Supported by NSF PCM8402368. We thank Dr. Elliot Stein and Mr. Edward LeMahieu for technical assistance.",

year = "1985",

month = nov,

day = "25",

doi = "10.1016/0006-8993(85)90373-7",

language = "English",

volume = "348",

pages = "163--167",

number = "1",

}

TY - JOUR

T1 - Anticholinergic agents do not block light-induced circadian phase shifts

AU - Pauly, James R.

AU - Horseman, Nelson D.

N1 - Funding Information: Supported by NSF PCM8402368. We thank Dr. Elliot Stein and Mr. Edward LeMahieu for technical assistance.

PY - 1985/11/25

Y1 - 1985/11/25

N2 - Depletion of brain acetylcholine (ACh) stores by central infusions of hemicholinium-3 (HC-3) did not prevent the circadian phase-shifting effects of subsequent light pulses in rats. Animals treated with atropine likewise had normal responses to light pulses. Neither delay nor advance shifts were prevented. These data do not support the view that ACh is the primary mediator of photoentrainment in the rat. The previously reported effects of carbachol injections may be non-specific.

AB - Depletion of brain acetylcholine (ACh) stores by central infusions of hemicholinium-3 (HC-3) did not prevent the circadian phase-shifting effects of subsequent light pulses in rats. Animals treated with atropine likewise had normal responses to light pulses. Neither delay nor advance shifts were prevented. These data do not support the view that ACh is the primary mediator of photoentrainment in the rat. The previously reported effects of carbachol injections may be non-specific.

KW - acetylcholine

KW - circadian rhythm

KW - phase shift

KW - suprachiasmatic nucleus

UR - http://www.scopus.com/inward/record.url?scp=0022383942&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022383942&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(85)90373-7

DO - 10.1016/0006-8993(85)90373-7

M3 - Article

C2 - 4063821

AN - SCOPUS:0022383942

SN - 0006-8993

VL - 348

SP - 163

EP - 167

JO - Brain Research

JF - Brain Research

IS - 1

ER -

Anticholinergic agents do not block light-induced circadian phase shifts

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this