Anticholinergic agents do not block light-induced circadian phase shifts

James R. Pauly, Nelson D. Horseman

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Depletion of brain acetylcholine (ACh) stores by central infusions of hemicholinium-3 (HC-3) did not prevent the circadian phase-shifting effects of subsequent light pulses in rats. Animals treated with atropine likewise had normal responses to light pulses. Neither delay nor advance shifts were prevented. These data do not support the view that ACh is the primary mediator of photoentrainment in the rat. The previously reported effects of carbachol injections may be non-specific.

Original languageEnglish
Pages (from-to)163-167
Number of pages5
JournalBrain Research
Volume348
Issue number1
DOIs
StatePublished - Nov 25 1985

Bibliographical note

Funding Information:
Supported by NSF PCM8402368. We thank Dr. Elliot Stein and Mr. Edward LeMahieu for technical assistance.

Keywords

  • acetylcholine
  • circadian rhythm
  • phase shift
  • suprachiasmatic nucleus

ASJC Scopus subject areas

  • Neuroscience (all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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