Anticonvulsant effect of anacardic acid in murine models: Putative role of GABAergic and antioxidant mechanisms

Antonio Luiz Gomes, Jana Dimitrova Tchekalarova, Milena Atanasova, Keylla da Conceição Machado, Maria Alexsandra de Sousa Rios, Márcia Fernanda Paz Jardim, Mihnea Alexandru Găman, Amelia Maria Găman, Santosh Yele, Manik Chandra Shill, Ishaq N. Khan, Md Amirul Islam, Eunüs S. Ali, Siddhartha K. Mishra, Muhammad Torequl Islam, Mohammad S. Mubarak, Luciano da Silva Lopes, Ana Amélia de Carvalho Melo-Cavalcante

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Epilepsy is a neurological disease affecting people of all ages worldwide. Side effects of antiepileptic drugs and their association with oxidative stress stimulate the search for new drugs, which would be more affordable with fewer adverse effects. Accordingly, the aim of the present work is to evaluate the anticonvulsant effect of anacardic acid (AA), a natural compound extracted from cashew liquid (Anacardium occidentalis), in murine models, as well as its antioxidant actions in Saccharomyces cerevisiae. AA (>90% purity) was tested, in vivo, in male Swiss mice (25–30 g) with four convulsive models, (1) pentylenetetrazole, (2) pilocarpine, (3) electroshock, and (4) kainic acid, at doses of 25, 50, and 100 mg/kg, body weight (B.W.) Additionally, the effective dose, toxic dose, and protective index studies were also performed. Results revealed that AA exhibits anticonvulsive effects in models 1, 3, and 4, with a mean effective dose (ED50) of 39.64 (model 1) >100 mg/kg, B.W. (model 2), and 38.36 (model 3); furthermore, AA displays a protection index of 1.49 (model 1), <0.6 (model 2, and 1.54 (model 3). In addition, AA showed antioxidant activities in S. cerevisiae mutated for superoxide dismutases (SOD). In conclusion, these results show that AA exhibits significant anticonvulsant and antioxidant activities and may be used as a promising natural product for the treatment of epilepsy.

Original languageEnglish
Pages (from-to)1686-1695
Number of pages10
JournalBiomedicine and Pharmacotherapy
Volume106
DOIs
StatePublished - Oct 2018

Bibliographical note

Publisher Copyright:
© 2018 Elsevier Masson SAS

Keywords

  • Anacardic acid
  • Animal model
  • Convulsion
  • Epilepsy
  • Oxidative stress

ASJC Scopus subject areas

  • Pharmacology

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