TY - JOUR
T1 - Anticonvulsant effect of anacardic acid in murine models
T2 - Putative role of GABAergic and antioxidant mechanisms
AU - Luiz Gomes, Antonio
AU - Dimitrova Tchekalarova, Jana
AU - Atanasova, Milena
AU - da Conceição Machado, Keylla
AU - de Sousa Rios, Maria Alexsandra
AU - Paz Jardim, Márcia Fernanda
AU - Găman, Mihnea Alexandru
AU - Găman, Amelia Maria
AU - Yele, Santosh
AU - Shill, Manik Chandra
AU - Khan, Ishaq N.
AU - Islam, Md Amirul
AU - Ali, Eunüs S.
AU - Mishra, Siddhartha K.
AU - Islam, Muhammad Torequl
AU - Mubarak, Mohammad S.
AU - da Silva Lopes, Luciano
AU - de Carvalho Melo-Cavalcante, Ana Amélia
N1 - Publisher Copyright:
© 2018 Elsevier Masson SAS
PY - 2018/10
Y1 - 2018/10
N2 - Epilepsy is a neurological disease affecting people of all ages worldwide. Side effects of antiepileptic drugs and their association with oxidative stress stimulate the search for new drugs, which would be more affordable with fewer adverse effects. Accordingly, the aim of the present work is to evaluate the anticonvulsant effect of anacardic acid (AA), a natural compound extracted from cashew liquid (Anacardium occidentalis), in murine models, as well as its antioxidant actions in Saccharomyces cerevisiae. AA (>90% purity) was tested, in vivo, in male Swiss mice (25–30 g) with four convulsive models, (1) pentylenetetrazole, (2) pilocarpine, (3) electroshock, and (4) kainic acid, at doses of 25, 50, and 100 mg/kg, body weight (B.W.) Additionally, the effective dose, toxic dose, and protective index studies were also performed. Results revealed that AA exhibits anticonvulsive effects in models 1, 3, and 4, with a mean effective dose (ED50) of 39.64 (model 1) >100 mg/kg, B.W. (model 2), and 38.36 (model 3); furthermore, AA displays a protection index of 1.49 (model 1), <0.6 (model 2, and 1.54 (model 3). In addition, AA showed antioxidant activities in S. cerevisiae mutated for superoxide dismutases (SOD). In conclusion, these results show that AA exhibits significant anticonvulsant and antioxidant activities and may be used as a promising natural product for the treatment of epilepsy.
AB - Epilepsy is a neurological disease affecting people of all ages worldwide. Side effects of antiepileptic drugs and their association with oxidative stress stimulate the search for new drugs, which would be more affordable with fewer adverse effects. Accordingly, the aim of the present work is to evaluate the anticonvulsant effect of anacardic acid (AA), a natural compound extracted from cashew liquid (Anacardium occidentalis), in murine models, as well as its antioxidant actions in Saccharomyces cerevisiae. AA (>90% purity) was tested, in vivo, in male Swiss mice (25–30 g) with four convulsive models, (1) pentylenetetrazole, (2) pilocarpine, (3) electroshock, and (4) kainic acid, at doses of 25, 50, and 100 mg/kg, body weight (B.W.) Additionally, the effective dose, toxic dose, and protective index studies were also performed. Results revealed that AA exhibits anticonvulsive effects in models 1, 3, and 4, with a mean effective dose (ED50) of 39.64 (model 1) >100 mg/kg, B.W. (model 2), and 38.36 (model 3); furthermore, AA displays a protection index of 1.49 (model 1), <0.6 (model 2, and 1.54 (model 3). In addition, AA showed antioxidant activities in S. cerevisiae mutated for superoxide dismutases (SOD). In conclusion, these results show that AA exhibits significant anticonvulsant and antioxidant activities and may be used as a promising natural product for the treatment of epilepsy.
KW - Anacardic acid
KW - Animal model
KW - Convulsion
KW - Epilepsy
KW - Oxidative stress
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U2 - 10.1016/j.biopha.2018.07.121
DO - 10.1016/j.biopha.2018.07.121
M3 - Article
C2 - 30170356
AN - SCOPUS:85050623922
SN - 0753-3322
VL - 106
SP - 1686
EP - 1695
JO - Biomedicine and Pharmacotherapy
JF - Biomedicine and Pharmacotherapy
ER -