Antidepressants do not improve event-free survival in patients with heart failure when depressive symptoms remain

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26 Scopus citations

Abstract

Objective: The purpose of this secondary data analysis was to compare event-free survival among four groups of patients with heart failure (HF) that were stratified by presence of depressive symptoms and antidepressants. Methods: We analyzed data from 209 outpatients (30.6% female, 62 ± 12 years, 54% NYHA Class III/IV) enrolled in a multicenter HF registry who had data on depressive symptoms, antidepressant use, and cardiac rehospitalization and death outcomes during 1 year follow up. Depressive symptoms were assessed using the Patient Health Questionnaire-9. Results: Depressive symptoms, not antidepressant therapy, predicted event-free survival (HR = 2.4, 95% CI = 1.2-4.6, p = .009). Depressed patients without antidepressants had 4.1 times higher risk of death and hospitalization than non-depressed patients on antidepressant (95% CI = 1.2-13.9, p = .022) after controlling for age, gender, NYHA class, body mass index, diabetes, medication of ACEI and beta-blockers. Conclusion: Antidepressant use was not a predictor of event-free survival outcomes when patients still reported depressive symptoms. Ongoing assessment of patients on antidepressants is needed to assure adequate treatment.

Original languageEnglish
Pages (from-to)85-91
Number of pages7
JournalHeart and Lung: Journal of Acute and Critical Care
Volume42
Issue number2
DOIs
StatePublished - Mar 2013

Bibliographical note

Funding Information:
This research was funded by the National Institutes of Health, National Institute of Nursing Research R01 NR 008567 , R01 NR 009280 , NINR P20 NR010679 , and NIH M01 RR02602 . The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Nursing Research or the National Institutes of Health.

Keywords

  • Antidepressants
  • Depressive symptoms
  • Heart failure
  • Mortality

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

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