Antidromic vasodilation in frog: identification of the nerve fiber types involved

V. M. Khayutin, Raisa S. Sonina, G. I. Frolenkov, I. M. Zizin

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


In anesthetized, immobilized frogs arteriolar vasodilation in the submaxillaris muscle in response to electrical stimulation of the submaxillar nerve (peripheral end) was observed directly and vasodilation in the hind leg in response to stimulation of the sciatic nerve (peripheral end) measured by plethysmography. With pulses of 0.1 ms duration at 20 Hz, the threshold for arteriolar vasodilation in the submaxillaris muscle was close to 3 T, where T was the activation threshold of the most excitable fraction of motor fibers of the submaxillar nerve. Atropine had no effect on the arteriolar vasodilation. When the sciatic nerve was stimulated with pulses of 0.1 ms duration, the threshold for vasodilation in the hind leg was 3.6±1.2 T (mean ± SEM). The thresholds for excitation of the Aαβ, Aδ and C-afferent fibers in the sciatic nerve and the range of stimulus intensities for recruiting each of these fiber groups were evaluated by recording compound action potentials in the VIII-X dorsal roots. Excitation of Aδ-afferent fibers was found to occur in the same intensity range as that which evoked vasodilation in the hind leg. It is concluded that, in the frog, these myelinated afferent fibers are capable of dilating the blood vessels by antidromic action in both submaxillaris muscle and hind leg. This finding is in accordance with recent reports of an antidromic vasodilator action of Aδ-afferent fibers in rabbit and rat skin.

Original languageEnglish
Pages (from-to)508-513
Number of pages6
JournalPflugers Archiv European Journal of Physiology
Issue number5
StatePublished - Nov 1991


  • A-afferents
  • Arterioles
  • Frog
  • Skeletal muscle
  • Submaxillar and sciatic nerves
  • Vasodilatation

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Physiology (medical)


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