TY - JOUR
T1 - Antiepileptic dosing for critically ill adult patients receiving renal replacement therapy
AU - Smetana, Keaton S.
AU - Cook, Aaron M.
AU - Bastin, Melissa L.Thompson
AU - Oyler, Douglas R.
N1 - Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Objectives The aim of this review was to evaluate current literature for dosing recommendations for the use of antiepileptic medications in patients receiving renal replacement therapy (RRT). Data sources With the assistance of an experienced medical librarian specialized in pharmacy and toxicology, we searched MEDLINE, EMBASE, CINAHL, Web of Science, WorldCat, and Scopus through May 2016. Study selection and data extraction Four hundred three articles were screened for inclusion, of which 130 were identified as potentially relevant. Micromedex® DRUGDEX as well as package inserts were used to obtain known pharmacokinetic properties and dosage adjustment recommendations in RRT if known. Data synthesis Data regarding antiepileptic drug use in RRT are limited and mostly consist of case reports limiting our proposed dosing recommendations. Known pharmacokinetic parameters should guide dosing, and recommendations are provided where possible. Conclusion Additional studies are necessary before specific dosing recommendations can be made for most antiepileptic drugs in critically ill patients receiving RRT, specifically with newer agents.
AB - Objectives The aim of this review was to evaluate current literature for dosing recommendations for the use of antiepileptic medications in patients receiving renal replacement therapy (RRT). Data sources With the assistance of an experienced medical librarian specialized in pharmacy and toxicology, we searched MEDLINE, EMBASE, CINAHL, Web of Science, WorldCat, and Scopus through May 2016. Study selection and data extraction Four hundred three articles were screened for inclusion, of which 130 were identified as potentially relevant. Micromedex® DRUGDEX as well as package inserts were used to obtain known pharmacokinetic properties and dosage adjustment recommendations in RRT if known. Data synthesis Data regarding antiepileptic drug use in RRT are limited and mostly consist of case reports limiting our proposed dosing recommendations. Known pharmacokinetic parameters should guide dosing, and recommendations are provided where possible. Conclusion Additional studies are necessary before specific dosing recommendations can be made for most antiepileptic drugs in critically ill patients receiving RRT, specifically with newer agents.
KW - Anticonvulsants
KW - Continuous renal replacement therapy
KW - Hemodialysis
KW - Intensive care
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U2 - 10.1016/j.jcrc.2016.06.023
DO - 10.1016/j.jcrc.2016.06.023
M3 - Review article
C2 - 27546759
AN - SCOPUS:84995581810
SN - 0883-9441
VL - 36
SP - 116
EP - 124
JO - Journal of Critical Care
JF - Journal of Critical Care
ER -