Antigenic and genetic evolution of equine H3N8 influenza A viruses

J. M. Daly, A. C.K. Lai, M. M. Binns, T. M. Chambers, M. Barrandeguy, J. A. Mumford

Research output: Contribution to journalArticlepeer-review

190 Scopus citations

Abstract

Evolution of equine influenza A H3N8 viruses was examined by antigenic and genetic analysis of a collection of isolates from around the world. It was noted that antigenic and genetic variants of equine H3N8 viruses cocirculate, and in particular that variants currently circulating in Europe and the USA are distinguishable from one another both in terms of antigenic reactivity and genetic structure of the HA1 portion of the haemagglutinin (HA) molecule. Whilst the divergent evolution of American and European isolates may be due to geographical isolation of the two gene pools, some mixing is believed to occur as 'American-like' viruses have been isolated during outbreaks of equine influenza in the UK. The cocirculation of two antigenically and genetically distinct lineages of equine influenza H3N8 viruses has serious implications for vaccine strain selection.

Original languageEnglish
Pages (from-to)661-671
Number of pages11
JournalJournal of General Virology
Volume77
Issue number4
DOIs
StatePublished - 1996

ASJC Scopus subject areas

  • Virology

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