TY - JOUR
T1 - Antigenic changes in gp70 associated with the adult variant of Gross murine leukemia virus, WB91
AU - Jones, S. M.
AU - Spear, B. T.
AU - Klyczek, K. K.
AU - Pozsgay, J. M.
AU - Gaudet, E.
AU - Yao, D.
AU - Blank, K. J.
PY - 1986/6
Y1 - 1986/6
N2 - Gross murine leukemia virus (GV) is not leukemogenic in adult mice whereas a variant of GV, WB91, is highly leukemogenic regardless of the age of the inoculated animal. FACS and SDS-PAGE analysis have demonstrated that these viruses differ at least with respect to the env-encoded gp70 molecule. FACS analysis of virus infected or virus transformed cells with a type specific monoclonal antibody (mAb #55) indicated a difference in determinants associated with gp70 expressed by the two viruses. Rat antisera raised against GV- or WB91-induced tumor cells demonstrated that there were no crossreactive determinants between the gp70 molecules expressed on these tumor cells as recognized by the rat antisera. This difference in the gp70 molecules encoded by WB91 and GV may account for the ability of the WB91 virus to induce leukemia in adult mice, possibly by affecting the immunogenicity of the virus.
AB - Gross murine leukemia virus (GV) is not leukemogenic in adult mice whereas a variant of GV, WB91, is highly leukemogenic regardless of the age of the inoculated animal. FACS and SDS-PAGE analysis have demonstrated that these viruses differ at least with respect to the env-encoded gp70 molecule. FACS analysis of virus infected or virus transformed cells with a type specific monoclonal antibody (mAb #55) indicated a difference in determinants associated with gp70 expressed by the two viruses. Rat antisera raised against GV- or WB91-induced tumor cells demonstrated that there were no crossreactive determinants between the gp70 molecules expressed on these tumor cells as recognized by the rat antisera. This difference in the gp70 molecules encoded by WB91 and GV may account for the ability of the WB91 virus to induce leukemia in adult mice, possibly by affecting the immunogenicity of the virus.
KW - gp 70 molecule
KW - murine leukemia virus
KW - type specific determinants
KW - variant Gross virus
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U2 - 10.1016/0882-4010(86)90052-5
DO - 10.1016/0882-4010(86)90052-5
M3 - Article
C2 - 3508491
AN - SCOPUS:0022491113
SN - 0882-4010
VL - 1
SP - 275
EP - 282
JO - Microbial Pathogenesis
JF - Microbial Pathogenesis
IS - 3
ER -
