Antigenic changes in gp70 associated with the adult variant of Gross murine leukemia virus, WB91

S. M. Jones; B. T. Spear; K. K. Klyczek; J. M. Pozsgay; E. Gaudet; D. Yao; K. J. Blank

doi:10.1016/0882-4010(86)90052-5

Antigenic changes in gp70 associated with the adult variant of Gross murine leukemia virus, WB91

S. M. Jones, B. T. Spear, K. K. Klyczek, J. M. Pozsgay, E. Gaudet, D. Yao, K. J. Blank

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Gross murine leukemia virus (GV) is not leukemogenic in adult mice whereas a variant of GV, WB91, is highly leukemogenic regardless of the age of the inoculated animal. FACS and SDS-PAGE analysis have demonstrated that these viruses differ at least with respect to the env-encoded gp70 molecule. FACS analysis of virus infected or virus transformed cells with a type specific monoclonal antibody (mAb #55) indicated a difference in determinants associated with gp70 expressed by the two viruses. Rat antisera raised against GV- or WB91-induced tumor cells demonstrated that there were no crossreactive determinants between the gp70 molecules expressed on these tumor cells as recognized by the rat antisera. This difference in the gp70 molecules encoded by WB91 and GV may account for the ability of the WB91 virus to induce leukemia in adult mice, possibly by affecting the immunogenicity of the virus.

Original language	English
Pages (from-to)	275-282
Number of pages	8
Journal	Microbial Pathogenesis
Volume	1
Issue number	3
DOIs	https://doi.org/10.1016/0882-4010(86)90052-5
State	Published - Jun 1986

Keywords

gp 70 molecule
murine leukemia virus
type specific determinants
variant Gross virus

ASJC Scopus subject areas

Microbiology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0882-4010(86)90052-5

Cite this

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title = "Antigenic changes in gp70 associated with the adult variant of Gross murine leukemia virus, WB91",

abstract = "Gross murine leukemia virus (GV) is not leukemogenic in adult mice whereas a variant of GV, WB91, is highly leukemogenic regardless of the age of the inoculated animal. FACS and SDS-PAGE analysis have demonstrated that these viruses differ at least with respect to the env-encoded gp70 molecule. FACS analysis of virus infected or virus transformed cells with a type specific monoclonal antibody (mAb #55) indicated a difference in determinants associated with gp70 expressed by the two viruses. Rat antisera raised against GV- or WB91-induced tumor cells demonstrated that there were no crossreactive determinants between the gp70 molecules expressed on these tumor cells as recognized by the rat antisera. This difference in the gp70 molecules encoded by WB91 and GV may account for the ability of the WB91 virus to induce leukemia in adult mice, possibly by affecting the immunogenicity of the virus.",

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author = "Jones, {S. M.} and Spear, {B. T.} and Klyczek, {K. K.} and Pozsgay, {J. M.} and E. Gaudet and D. Yao and Blank, {K. J.}",

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T1 - Antigenic changes in gp70 associated with the adult variant of Gross murine leukemia virus, WB91

AU - Jones, S. M.

AU - Spear, B. T.

AU - Klyczek, K. K.

AU - Pozsgay, J. M.

AU - Gaudet, E.

AU - Yao, D.

AU - Blank, K. J.

PY - 1986/6

Y1 - 1986/6

N2 - Gross murine leukemia virus (GV) is not leukemogenic in adult mice whereas a variant of GV, WB91, is highly leukemogenic regardless of the age of the inoculated animal. FACS and SDS-PAGE analysis have demonstrated that these viruses differ at least with respect to the env-encoded gp70 molecule. FACS analysis of virus infected or virus transformed cells with a type specific monoclonal antibody (mAb #55) indicated a difference in determinants associated with gp70 expressed by the two viruses. Rat antisera raised against GV- or WB91-induced tumor cells demonstrated that there were no crossreactive determinants between the gp70 molecules expressed on these tumor cells as recognized by the rat antisera. This difference in the gp70 molecules encoded by WB91 and GV may account for the ability of the WB91 virus to induce leukemia in adult mice, possibly by affecting the immunogenicity of the virus.

AB - Gross murine leukemia virus (GV) is not leukemogenic in adult mice whereas a variant of GV, WB91, is highly leukemogenic regardless of the age of the inoculated animal. FACS and SDS-PAGE analysis have demonstrated that these viruses differ at least with respect to the env-encoded gp70 molecule. FACS analysis of virus infected or virus transformed cells with a type specific monoclonal antibody (mAb #55) indicated a difference in determinants associated with gp70 expressed by the two viruses. Rat antisera raised against GV- or WB91-induced tumor cells demonstrated that there were no crossreactive determinants between the gp70 molecules expressed on these tumor cells as recognized by the rat antisera. This difference in the gp70 molecules encoded by WB91 and GV may account for the ability of the WB91 virus to induce leukemia in adult mice, possibly by affecting the immunogenicity of the virus.

KW - gp 70 molecule

KW - murine leukemia virus

KW - type specific determinants

KW - variant Gross virus

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Antigenic changes in gp70 associated with the adult variant of Gross murine leukemia virus, WB91

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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