Antimicrobial options in the treatment of adult staphylococcal bone and joint infections in an era of drug shortages

Allison L. Mruk, Kenneth E. Record

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Staphylococcus aureus is the most pathogenic bacterium and the most common cause of osteomyelitis, affecting 50% to 70% of cases. Many antistaphylococcal agents with varying activity against methicillin-susceptible S aureus and methicillin-resistant S aureus are available in the US market. This article reviews the most common antistaphylococcal agents used in the treatment of bone and joint infections in adult patients and focuses on the antimicrobial agent's mechanism of action, US Food and Drug Administration-approved indications, place in therapy, monitoring parameters, and common side effects.

Original languageEnglish
Pages (from-to)401-407
Number of pages7
JournalOrthopedics
Volume35
Issue number5
DOIs
StatePublished - May 2012

ASJC Scopus subject areas

  • Surgery
  • Medicine (all)

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