Antioncogenic and oncogenic properties of Nrf2 in arsenic-induced carcinogenesis

Young Ok Son; Poyil Pratheeshkumar; Ram Vinod Roy; John Andrew Hitron; Lei Wang; Sasidharan Padmaja Divya; Mei Xu; Jia Luo; Gang Chen; Zhuo Zhang; Xianglin Shi

doi:10.1074/jbc.M115.675371

Antioncogenic and oncogenic properties of Nrf2 in arsenic-induced carcinogenesis

Young Ok Son, Poyil Pratheeshkumar, Ram Vinod Roy, John Andrew Hitron, Lei Wang, Sasidharan Padmaja Divya, Mei Xu, Jia Luo, Gang Chen, Zhuo Zhang, Xianglin Shi

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Background: Arsenic induced cell transformation and carcinogenesis. Results: Arsenic-transformed cells have the property of apoptosis/autophagy resistance. Conclusion: The constitutive activation of Nrf2 in arsenic-transformed cells up-regulates antioxidants, decreases ROS generation, and causes apoptosis resistance and tumorigenesis. Significance: Antioncogenic role of inducible Nrf2 in normal cells and oncogenic role of constitutive activation of Nfr2 in cancer cells may increase our understanding of the mechanism of arsenic carcinogenesis and its prevention.

Original language	English
Pages (from-to)	27090-27100
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	290
Issue number	45
DOIs	https://doi.org/10.1074/jbc.M115.675371
State	Published - Nov 6 2015

Bibliographical note

Publisher Copyright:
© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

Funding

Funders	Funder number
National Institutes of Health (NIH)	R01 ES021771, R01 ES025515
National Institutes of Health/National Institute of Environmental Health Sciences	T32ES007266

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

UN SDGs

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10.1074/jbc.M115.675371

Cite this

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title = "Antioncogenic and oncogenic properties of Nrf2 in arsenic-induced carcinogenesis",

abstract = "Background: Arsenic induced cell transformation and carcinogenesis. Results: Arsenic-transformed cells have the property of apoptosis/autophagy resistance. Conclusion: The constitutive activation of Nrf2 in arsenic-transformed cells up-regulates antioxidants, decreases ROS generation, and causes apoptosis resistance and tumorigenesis. Significance: Antioncogenic role of inducible Nrf2 in normal cells and oncogenic role of constitutive activation of Nfr2 in cancer cells may increase our understanding of the mechanism of arsenic carcinogenesis and its prevention.",

author = "Son, {Young Ok} and Poyil Pratheeshkumar and Roy, {Ram Vinod} and Hitron, {John Andrew} and Lei Wang and Divya, {Sasidharan Padmaja} and Mei Xu and Jia Luo and Gang Chen and Zhuo Zhang and Xianglin Shi",

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doi = "10.1074/jbc.M115.675371",

language = "English",

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T1 - Antioncogenic and oncogenic properties of Nrf2 in arsenic-induced carcinogenesis

AU - Son, Young Ok

AU - Pratheeshkumar, Poyil

AU - Roy, Ram Vinod

AU - Hitron, John Andrew

AU - Wang, Lei

AU - Divya, Sasidharan Padmaja

AU - Xu, Mei

AU - Luo, Jia

AU - Chen, Gang

AU - Zhang, Zhuo

AU - Shi, Xianglin

PY - 2015/11/6

Y1 - 2015/11/6

N2 - Background: Arsenic induced cell transformation and carcinogenesis. Results: Arsenic-transformed cells have the property of apoptosis/autophagy resistance. Conclusion: The constitutive activation of Nrf2 in arsenic-transformed cells up-regulates antioxidants, decreases ROS generation, and causes apoptosis resistance and tumorigenesis. Significance: Antioncogenic role of inducible Nrf2 in normal cells and oncogenic role of constitutive activation of Nfr2 in cancer cells may increase our understanding of the mechanism of arsenic carcinogenesis and its prevention.

AB - Background: Arsenic induced cell transformation and carcinogenesis. Results: Arsenic-transformed cells have the property of apoptosis/autophagy resistance. Conclusion: The constitutive activation of Nrf2 in arsenic-transformed cells up-regulates antioxidants, decreases ROS generation, and causes apoptosis resistance and tumorigenesis. Significance: Antioncogenic role of inducible Nrf2 in normal cells and oncogenic role of constitutive activation of Nfr2 in cancer cells may increase our understanding of the mechanism of arsenic carcinogenesis and its prevention.

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M3 - Article

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SN - 0021-9258

VL - 290

SP - 27090

EP - 27100

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

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ER -

Antioncogenic and oncogenic properties of Nrf2 in arsenic-induced carcinogenesis

Abstract

Bibliographical note

Funding

ASJC Scopus subject areas

UN SDGs

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