TY - JOUR
T1 - Antioncogenic and oncogenic properties of Nrf2 in arsenic-induced carcinogenesis
AU - Son, Young Ok
AU - Pratheeshkumar, Poyil
AU - Roy, Ram Vinod
AU - Hitron, John Andrew
AU - Wang, Lei
AU - Divya, Sasidharan Padmaja
AU - Xu, Mei
AU - Luo, Jia
AU - Chen, Gang
AU - Zhang, Zhuo
AU - Shi, Xianglin
N1 - Publisher Copyright:
© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.
PY - 2015/11/6
Y1 - 2015/11/6
N2 - Background: Arsenic induced cell transformation and carcinogenesis. Results: Arsenic-transformed cells have the property of apoptosis/autophagy resistance. Conclusion: The constitutive activation of Nrf2 in arsenic-transformed cells up-regulates antioxidants, decreases ROS generation, and causes apoptosis resistance and tumorigenesis. Significance: Antioncogenic role of inducible Nrf2 in normal cells and oncogenic role of constitutive activation of Nfr2 in cancer cells may increase our understanding of the mechanism of arsenic carcinogenesis and its prevention.
AB - Background: Arsenic induced cell transformation and carcinogenesis. Results: Arsenic-transformed cells have the property of apoptosis/autophagy resistance. Conclusion: The constitutive activation of Nrf2 in arsenic-transformed cells up-regulates antioxidants, decreases ROS generation, and causes apoptosis resistance and tumorigenesis. Significance: Antioncogenic role of inducible Nrf2 in normal cells and oncogenic role of constitutive activation of Nfr2 in cancer cells may increase our understanding of the mechanism of arsenic carcinogenesis and its prevention.
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U2 - 10.1074/jbc.M115.675371
DO - 10.1074/jbc.M115.675371
M3 - Article
C2 - 26385919
AN - SCOPUS:84946781660
SN - 0021-9258
VL - 290
SP - 27090
EP - 27100
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 45
ER -
