Abstract
Background: Arsenic induced cell transformation and carcinogenesis. Results: Arsenic-transformed cells have the property of apoptosis/autophagy resistance. Conclusion: The constitutive activation of Nrf2 in arsenic-transformed cells up-regulates antioxidants, decreases ROS generation, and causes apoptosis resistance and tumorigenesis. Significance: Antioncogenic role of inducible Nrf2 in normal cells and oncogenic role of constitutive activation of Nfr2 in cancer cells may increase our understanding of the mechanism of arsenic carcinogenesis and its prevention.
| Original language | English |
|---|---|
| Pages (from-to) | 27090-27100 |
| Number of pages | 11 |
| Journal | Journal of Biological Chemistry |
| Volume | 290 |
| Issue number | 45 |
| DOIs | |
| State | Published - Nov 6 2015 |
Bibliographical note
Publisher Copyright:© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.
Funding
| Funders | Funder number |
|---|---|
| National Institutes of Health (NIH) | R01 ES021771, R01 ES025515 |
| National Institutes of Health/National Institute of Environmental Health Sciences | T32ES007266 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology
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