Antioxidant agents in Alzheimer's disease

Patrizia Mecocci, E. Mariani, M. C. Polidori, K. Hensley, D. A. Butterfield

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


Understanding the molecular mechanisms of neurodegeneration represents a scientific priority as it will allow scientists to more specifically target and simultaneously interrupt the multiple pathologic mechanisms that contribute to the progression of dementia in Alzheimer's disease (AD). Oxidative stress represents one of the key processes in AD pathogenesis, related to formation of both amyloid plaques and neurofibrillary tangles as well as to alteration of many biomolecules. For this reason several antioxidant molecules have been tested in in vitro and in vivo studies in order to detect more efficacious treatments. Dietary antioxidants seem also to have an important role in AD prevention, as shown by several epidemiological studies. Ongoing clinical trials to assess whether antioxidant supplementation has a role in primary prevention of AD or in delaying the progression of disease in individuals with Mild Cognitive Impairment (MCI), are in progress or planned. Thus, research involving new antioxidants and their potential clinical applications will provide new insights into the molecular basis of neuroprotective mechanisms that may be relevant to AD and other age-related neurodegenerative disorders.

Original languageEnglish
Pages (from-to)48-63
Number of pages16
JournalCentral Nervous System Agents in Medicinal Chemistry
Issue number1
StatePublished - Mar 2008


  • Alzheimer's disease
  • Antioxidant
  • Diet
  • Mild cognitive impairment
  • Oxidative stress
  • Treatment

ASJC Scopus subject areas

  • Neuroscience (all)
  • Neuropsychology and Physiological Psychology
  • Molecular Medicine


Dive into the research topics of 'Antioxidant agents in Alzheimer's disease'. Together they form a unique fingerprint.

Cite this