Abstract
The antioxidant effect of an aqueous extract of Phaseolus vulgaris pods, an indigenous plant used in Ayurvedic medicine in India, was studied in rats with streptozotocin-induced diabetes. Oral administration of Phaseolus vulgaris pod extract (PPEt; 200 mg/kg body weight) for 45 days resulted in a significant reduction in thiobarbituric acid reactive substances and hydroperoxides. The extract also causes a significant increase in reduced glutathione, superoxide dismutase, catalase, glutathione peroxidase and glutathione-S-transferase in the liver and kidneys of rats with streptozotocin-induced diabetes. These results clearly show the antioxidant property of PPEt. The effect of PPEt at 200 mg/kg body weight was more effective than glibenclamide.
| Original language | English |
|---|---|
| Pages (from-to) | 206-209 |
| Number of pages | 4 |
| Journal | Asia Pacific Journal of Clinical Nutrition |
| Volume | 11 |
| Issue number | 3 |
| DOIs | |
| State | Published - 2002 |
Keywords
- Aqueous extract
- Enzymic antioxidants
- Phaseolus vulgaris
- Streptozotocin-induced diabetes
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics
