Antioxidant function of metallothioneins

Kelley Kiningham, Edward Kasarskis

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Since the discovery of metallothionein in 1957, it has been accepted that the primary roles of this protein are: 1) detoxification of heavy metals, and 2) regulation of the metabolism of essential metals. Recently, studies have suggested an additional role for metallothionein as a free radical scavenger. This article reviews in vitro and in vivo evidence which supports the role for metallothionein in modulation of reactive oxygen species.

Original languageEnglish
Pages (from-to)219-226
Number of pages8
JournalJournal of Trace Elements in Experimental Medicine
Issue number2-3
StatePublished - 1998


  • Antioxidant
  • Free radical
  • Metallothionein
  • Zinc

ASJC Scopus subject areas

  • Biochemistry


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