TY - JOUR
T1 - Antioxidant function of metallothioneins
AU - Kiningham, Kelley
AU - Kasarskis, Edward
PY - 1998
Y1 - 1998
N2 - Since the discovery of metallothionein in 1957, it has been accepted that the primary roles of this protein are: 1) detoxification of heavy metals, and 2) regulation of the metabolism of essential metals. Recently, studies have suggested an additional role for metallothionein as a free radical scavenger. This article reviews in vitro and in vivo evidence which supports the role for metallothionein in modulation of reactive oxygen species.
AB - Since the discovery of metallothionein in 1957, it has been accepted that the primary roles of this protein are: 1) detoxification of heavy metals, and 2) regulation of the metabolism of essential metals. Recently, studies have suggested an additional role for metallothionein as a free radical scavenger. This article reviews in vitro and in vivo evidence which supports the role for metallothionein in modulation of reactive oxygen species.
KW - Antioxidant
KW - Free radical
KW - Metallothionein
KW - Zinc
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U2 - 10.1002/(SICI)1520-670X(1998)11:2/3<219::AID-JTRA12>3.0.CO;2-U
DO - 10.1002/(SICI)1520-670X(1998)11:2/3<219::AID-JTRA12>3.0.CO;2-U
M3 - Article
AN - SCOPUS:0031879594
SN - 0896-548X
VL - 11
SP - 219
EP - 226
JO - Journal of Trace Elements in Experimental Medicine
JF - Journal of Trace Elements in Experimental Medicine
IS - 2-3
ER -