Antioxidant therapies in traumatic brain and spinal cord injury

Mona Bains, Edward D. Hall

Research output: Contribution to journalReview articlepeer-review

370 Scopus citations

Abstract

Free radical formation and oxidative damage have been extensively investigated and validated as important contributors to the pathophysiology of acute central nervous system injury. The generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) is an early event following injury occurring within minutes of mechanical impact. A key component in this event is peroxynitrite-induced lipid peroxidation. As discussed in this review, peroxynitrite formation and lipid peroxidation irreversibly damages neuronal membrane lipids and protein function, which results in subsequent disruptions in ion homeostasis, glutamate-mediated excitotoxicity, mitochondrial respiratory failure and microvascular damage. Antioxidant approaches include the inhibition and/or scavenging of superoxide, peroxynitrite, or carbonyl compounds, the inhibition of lipid peroxidation and the targeting of the endogenous antioxidant defense system. This review covers the preclinical and clinical literature supporting the role of ROS and RNS and their derived oxygen free radicals in the secondary injury response following acute traumatic brain injury (TBI) and spinal cord injury (SCI) and reviews the past and current trends in the development of antioxidant therapeutic strategies. Combinatorial treatment with the suggested mechanistically complementary antioxidants will also be discussed as a promising neuroprotective approach in TBI and SCI therapeutic research. This article is part of a Special Issue entitled: Antioxidants and antioxidant treatment in disease.

Original languageEnglish
Pages (from-to)675-684
Number of pages10
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Volume1822
Issue number5
DOIs
StatePublished - May 2012

Bibliographical note

Funding Information:
Some of the work reviewed in this article was supported by funding from the Kentucky Spinal Cord & Head Injury Trust .

Keywords

  • Antioxidant
  • Lipid peroxidation
  • Oxidative damage
  • Reactive oxygen species
  • Spinal cord injury
  • Traumatic brain injury

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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