Antitumor antibiotics: Bleomycin, enediynes, and mitomycin

Ute Galm; Martin H. Hager; Steven G. Van Lanen; Jianhua Ju; Jon S. Thorson; Ben Shen

doi:10.1021/cr030117g

Antitumor antibiotics: Bleomycin, enediynes, and mitomycin

Ute Galm, Martin H. Hager, Steven G. Van Lanen, Jianhua Ju, Jon S. Thorson, Ben Shen

Research output: Contribution to journal › Review article › peer-review

462 Scopus citations

Abstract

Natural-product-derived cytotoxics are still widely used in chemotherapy. A review is given of the current level of understanding and emerging trends relevant to the DNA-damaging metabolite families of the bleomycins, 9- and 10-membered enediynes, and mitomycins. A comparison of resistance mechanisms within producing organisms and those predominant among tumor cells reveals potential for continued development of these essential anticancer agents.

Original language	English
Pages (from-to)	739-758
Number of pages	20
Journal	Chemical Reviews
Volume	105
Issue number	2
DOIs	https://doi.org/10.1021/cr030117g
State	Published - Feb 2005

ASJC Scopus subject areas

Chemistry (all)

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10.1021/cr030117g

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title = "Antitumor antibiotics: Bleomycin, enediynes, and mitomycin",

abstract = "Natural-product-derived cytotoxics are still widely used in chemotherapy. A review is given of the current level of understanding and emerging trends relevant to the DNA-damaging metabolite families of the bleomycins, 9- and 10-membered enediynes, and mitomycins. A comparison of resistance mechanisms within producing organisms and those predominant among tumor cells reveals potential for continued development of these essential anticancer agents.",

author = "Ute Galm and Hager, {Martin H.} and {Van Lanen}, {Steven G.} and Jianhua Ju and Thorson, {Jon S.} and Ben Shen",

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T2 - Bleomycin, enediynes, and mitomycin

AU - Galm, Ute

AU - Hager, Martin H.

AU - Van Lanen, Steven G.

AU - Ju, Jianhua

AU - Thorson, Jon S.

AU - Shen, Ben

PY - 2005/2

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AB - Natural-product-derived cytotoxics are still widely used in chemotherapy. A review is given of the current level of understanding and emerging trends relevant to the DNA-damaging metabolite families of the bleomycins, 9- and 10-membered enediynes, and mitomycins. A comparison of resistance mechanisms within producing organisms and those predominant among tumor cells reveals potential for continued development of these essential anticancer agents.

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Antitumor antibiotics: Bleomycin, enediynes, and mitomycin

Abstract

ASJC Scopus subject areas

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