Antitumor antibiotics: Bleomycin, enediynes, and mitomycin

Ute Galm, Martin H. Hager, Steven G. Van Lanen, Jianhua Ju, Jon S. Thorson, Ben Shen

Research output: Contribution to journalReview articlepeer-review

492 Scopus citations

Abstract

Natural-product-derived cytotoxics are still widely used in chemotherapy. A review is given of the current level of understanding and emerging trends relevant to the DNA-damaging metabolite families of the bleomycins, 9- and 10-membered enediynes, and mitomycins. A comparison of resistance mechanisms within producing organisms and those predominant among tumor cells reveals potential for continued development of these essential anticancer agents.

Original languageEnglish
Pages (from-to)739-758
Number of pages20
JournalChemical Reviews
Volume105
Issue number2
DOIs
StatePublished - Feb 2005

ASJC Scopus subject areas

  • General Chemistry

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