Antitumor antibiotics: Bleomycin, enediynes, and mitomycin

Ute Galm; Martin H. Hager; Steven G. Van Lanen; Jianhua Ju; Jon S. Thorson; Ben Shen

doi:10.1021/cr030117g

Antitumor antibiotics: Bleomycin, enediynes, and mitomycin

Ute Galm
, Martin H. Hager
, Steven G. Van Lanen
, Jianhua Ju
, Jon S. Thorson
, Ben Shen

Research output: Contribution to journal › Review article › peer-review

535 Scopus citations

Abstract

Natural-product-derived cytotoxics are still widely used in chemotherapy. A review is given of the current level of understanding and emerging trends relevant to the DNA-damaging metabolite families of the bleomycins, 9- and 10-membered enediynes, and mitomycins. A comparison of resistance mechanisms within producing organisms and those predominant among tumor cells reveals potential for continued development of these essential anticancer agents.

Original language	English
Pages (from-to)	739-758
Number of pages	20
Journal	Chemical Reviews
Volume	105
Issue number	2
DOIs	https://doi.org/10.1021/cr030117g
State	Published - Feb 2005

Funding

Funders	Funder number
National Childhood Cancer Registry – National Cancer Institute	R01CA078747

ASJC Scopus subject areas

General Chemistry

Access to Document

10.1021/cr030117g

Cite this

@article{d37165bc9c5d4a29b1d895b68a39db3a,

title = "Antitumor antibiotics: Bleomycin, enediynes, and mitomycin",

abstract = "Natural-product-derived cytotoxics are still widely used in chemotherapy. A review is given of the current level of understanding and emerging trends relevant to the DNA-damaging metabolite families of the bleomycins, 9- and 10-membered enediynes, and mitomycins. A comparison of resistance mechanisms within producing organisms and those predominant among tumor cells reveals potential for continued development of these essential anticancer agents.",

author = "Ute Galm and Hager, \{Martin H.\} and \{Van Lanen\}, \{Steven G.\} and Jianhua Ju and Thorson, \{Jon S.\} and Ben Shen",

year = "2005",

month = feb,

doi = "10.1021/cr030117g",

language = "English",

volume = "105",

pages = "739--758",

number = "2",

}

TY - JOUR

T1 - Antitumor antibiotics

T2 - Bleomycin, enediynes, and mitomycin

AU - Galm, Ute

AU - Hager, Martin H.

AU - Van Lanen, Steven G.

AU - Ju, Jianhua

AU - Thorson, Jon S.

AU - Shen, Ben

PY - 2005/2

Y1 - 2005/2

N2 - Natural-product-derived cytotoxics are still widely used in chemotherapy. A review is given of the current level of understanding and emerging trends relevant to the DNA-damaging metabolite families of the bleomycins, 9- and 10-membered enediynes, and mitomycins. A comparison of resistance mechanisms within producing organisms and those predominant among tumor cells reveals potential for continued development of these essential anticancer agents.

AB - Natural-product-derived cytotoxics are still widely used in chemotherapy. A review is given of the current level of understanding and emerging trends relevant to the DNA-damaging metabolite families of the bleomycins, 9- and 10-membered enediynes, and mitomycins. A comparison of resistance mechanisms within producing organisms and those predominant among tumor cells reveals potential for continued development of these essential anticancer agents.

UR - https://www.scopus.com/pages/publications/14844357291

UR - https://www.scopus.com/pages/publications/14844357291#tab=citedBy

U2 - 10.1021/cr030117g

DO - 10.1021/cr030117g

M3 - Review article

C2 - 15700963

AN - SCOPUS:14844357291

SN - 0009-2665

VL - 105

SP - 739

EP - 758

JO - Chemical Reviews

JF - Chemical Reviews

IS - 2

ER -

Antitumor antibiotics: Bleomycin, enediynes, and mitomycin

Abstract

Funding

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this