Abstract
The antitumor effect of formalin-fixed Toxoplasma organisms (f-Tp) as an immunostimulant on EL4 lymphoma was examined in Toxoplasma-infected syngeneic female C57B1/6 mice. A potent antitumor effect, a marked suppression of tumor growth, as well as a prolongation of lifespan. was induced by an injection with 107 f-Tp in a mixture of 2.5 × 105 EL4 cells. The antitumor effect of f-Tp could be observed regardless of the time, route, or dose of infection. The peritoneal exudate cells induced by f-Tp in Toxoplaswa-infected mice showed an antitumor activity when the cells were implanted with tumor cells in normal mice, indicating that the cells activated by f-Tp caused the antitumor effect of f-Tp. The effect of f-Tp on EL4 in Toxoplasma-infected mice was significantly stronger than that of 107 live bacillus Calmette-Guerin organisms (BCG) in BCG-sensitized mice.
| Original language | English |
|---|---|
| Pages (from-to) | 288-293 |
| Number of pages | 6 |
| Journal | Journal of Biological Response Modifiers |
| Volume | 5 |
| Issue number | 4 |
| State | Published - Aug 1986 |
Keywords
- Antitumor effect
- EL4
- Formalin-fixed toxoplasma organisms
- Toxoplasma gondii
ASJC Scopus subject areas
- Immunology
- Pharmacology
- Cancer Research
