Antiviral Actions of Double-Stranded RNA

Saurabh Chattopadhyay, Michifumi Yamashita, Ganes C. Sen

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Scopus citations


The host responds to virus infection by triggering various antiviral defense mechanisms, many of which are initiated by double-stranded (ds) RNA, which is often produced in virus-infected cells. Surprisingly, similar responses are also triggered by cellular dsRNA produced by necrotic, or otherwise stressed, uninfected cells; in human and mouse, such responses have been genetically linked to protection against several diseases of non-viral etiology. Thus, dsRNA has a wide role in mediating host defense. DsRNA is recognized, in the cell, by a large family of dsRNA-binding proteins, some of which share similar structural motifs that mediate the binding. Functionally, some of these proteins are dsRNA-dependent enzymes while others are signaling receptors that trigger transcription of a cohort of cellular genes, many of which encode antiviral proteins.

Original languageEnglish
Title of host publicationNucleic Acid Sensors and Antiviral Immunity
Number of pages22
ISBN (Electronic)9781498713658
StatePublished - Jan 1 2012

Bibliographical note

Publisher Copyright:
© 2013 by Taylor and Francis Group, LLC.

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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