The aortic wall is composed of highly dynamic cell populations and extracellular matrix. In response to changes in the biomechanical environment, aortic cells and extracellular matrix modulate their structure and functions to increase aortic wall strength and meet the hemodynamic demand. Compromise in the structural and functional integrity of aortic components leads to aortic degeneration, biomechanical failure, and the development of aortic aneurysms and dissections (AAD). A better understanding of the molecular pathogenesis of AAD will facilitate the development of effective medications to treat these conditions. Here, we summarize recent findings on AAD published in ATVB. In this issue, we focus on the dynamics of aortic cells and extracellular matrix in AAD; in the next issue, we will focus on the role of signaling pathways in AAD.
|Journal||Arteriosclerosis, Thrombosis, and Vascular Biology|
|State||Published - Mar 1 2020|
Bibliographical noteFunding Information:
Our research activities are supported by grants from the National Institutes of Health (NIH)/National Heart, Lung, and Blood Institute (HL131980, HL143359, HL127111, HL133723, HL139748, HL134731, and HL107326) and from the American Heart Association (AHA) Vascular Diseases Strategically Focused Research Networks (SFRN) (AHA18SFRN33960114, 33960163, and 33960253). The content in this article is solely the responsibility of the authors and does not necessarily represent the official views of the NIH and AHA. S.A. LeMaire’s work is supported, in part, by the Jimmy and Roberta Howell Professorship in Cardiovascular Surgery at Baylor College of Medicine.
© 2020 Lippincott Williams and Wilkins. All rights reserved.
- aortic aneurysm
- extracellular matrix
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine