TY - JOUR
T1 - Aortic Aneurysms and Dissections Series
T2 - Part II: Dynamic Signaling Responses in Aortic Aneurysms and Dissections
AU - Shen, Ying H.
AU - LeMaire, Scott A.
AU - Webb, Nancy R.
AU - Cassis, Lisa A.
AU - Daugherty, Alan
AU - Lu, Hong S.
N1 - Publisher Copyright:
© 2020 American Heart Association, Inc.
PY - 2020/4/1
Y1 - 2020/4/1
N2 - Aortic structure and function are controlled by the coordinated actions of different aortic cells and the extracellular matrix. Several pathways have been identified that control the aortic wall in a cell-type-specific manner and play diverse roles in various phases of aortic injury, repair, and remodeling. This complexity of signaling in the aortic wall poses challenges to the development of therapeutic strategies for treating aortic aneurysms and dissections. Here, in part II of this Recent Highlights series on aortic aneurysms and dissections, we will summarize recent studies published in Arteriosclerosis, Thrombosis, and Vascular Biology that have contributed to our knowledge of the signaling pathway-related mechanisms of aortic aneurysms and dissections.
AB - Aortic structure and function are controlled by the coordinated actions of different aortic cells and the extracellular matrix. Several pathways have been identified that control the aortic wall in a cell-type-specific manner and play diverse roles in various phases of aortic injury, repair, and remodeling. This complexity of signaling in the aortic wall poses challenges to the development of therapeutic strategies for treating aortic aneurysms and dissections. Here, in part II of this Recent Highlights series on aortic aneurysms and dissections, we will summarize recent studies published in Arteriosclerosis, Thrombosis, and Vascular Biology that have contributed to our knowledge of the signaling pathway-related mechanisms of aortic aneurysms and dissections.
KW - angiotensin II receptor
KW - aorta
KW - aortic aneurysms
KW - signal transduction pathways
KW - transforming growth factor
UR - http://www.scopus.com/inward/record.url?scp=85082380626&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85082380626&partnerID=8YFLogxK
U2 - 10.1161/ATVBAHA.120.313804
DO - 10.1161/ATVBAHA.120.313804
M3 - Review article
C2 - 32208998
AN - SCOPUS:85082380626
SN - 1079-5642
VL - 40
SP - E78-E86
JO - Arteriosclerosis, Thrombosis, and Vascular Biology
JF - Arteriosclerosis, Thrombosis, and Vascular Biology
IS - 4
ER -