Aortic Aneurysms and Dissections Series: Part II: Dynamic Signaling Responses in Aortic Aneurysms and Dissections

Ying H. Shen; Scott A. LeMaire; Nancy R. Webb; Lisa A. Cassis; Alan Daugherty; Hong S. Lu

doi:10.1161/ATVBAHA.120.313804

Aortic Aneurysms and Dissections Series: Part II: Dynamic Signaling Responses in Aortic Aneurysms and Dissections

Ying H. Shen, Scott A. LeMaire, Nancy R. Webb, Lisa A. Cassis, Alan Daugherty, Hong S. Lu

Research output: Contribution to journal › Review article › peer-review

20 Scopus citations

Abstract

Aortic structure and function are controlled by the coordinated actions of different aortic cells and the extracellular matrix. Several pathways have been identified that control the aortic wall in a cell-type-specific manner and play diverse roles in various phases of aortic injury, repair, and remodeling. This complexity of signaling in the aortic wall poses challenges to the development of therapeutic strategies for treating aortic aneurysms and dissections. Here, in part II of this Recent Highlights series on aortic aneurysms and dissections, we will summarize recent studies published in Arteriosclerosis, Thrombosis, and Vascular Biology that have contributed to our knowledge of the signaling pathway-related mechanisms of aortic aneurysms and dissections.

Original language	English
Pages (from-to)	E78-E86
Journal	Arteriosclerosis, Thrombosis, and Vascular Biology
Volume	40
Issue number	4
DOIs	https://doi.org/10.1161/ATVBAHA.120.313804
State	Published - Apr 1 2020

Bibliographical note

Publisher Copyright:
© 2020 American Heart Association, Inc.

Funding

Our research activities are supported by grants from the National Institutes of Health (NIH)/National Heart, Lung, and Blood Institute (HL131980, HL143359, HL127111, HL133723, HL139748, HL134731, and HL107326) and from the American Heart Association (AHA) Vascular Diseases Strategically Focused Research Networks (SFRN; AHA18SFRN33960114, 33960163, and 33960253). The content in this article is solely the responsibility of the authors and does not necessarily represent the official views of the NIH and AHA. S.A. LeMaire’s work is supported in part by the Jimmy and Roberta Howell Professorship in Cardiovascular Surgery at Baylor College of Medicine.

Funders	Funder number
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)	HL131980, R01HL134731, HL127111, HL133723, HL107326, HL143359, HL139748
National Heart, Lung, and Blood Institute (NHLBI)
American the American Heart Association	33960253, 33960163, AHA18SFRN33960114
American the American Heart Association

Keywords

angiotensin II receptor
aorta
aortic aneurysms
signal transduction pathways
transforming growth factor

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

Access to Document

10.1161/ATVBAHA.120.313804

Cite this

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abstract = "Aortic structure and function are controlled by the coordinated actions of different aortic cells and the extracellular matrix. Several pathways have been identified that control the aortic wall in a cell-type-specific manner and play diverse roles in various phases of aortic injury, repair, and remodeling. This complexity of signaling in the aortic wall poses challenges to the development of therapeutic strategies for treating aortic aneurysms and dissections. Here, in part II of this Recent Highlights series on aortic aneurysms and dissections, we will summarize recent studies published in Arteriosclerosis, Thrombosis, and Vascular Biology that have contributed to our knowledge of the signaling pathway-related mechanisms of aortic aneurysms and dissections.",

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AU - Cassis, Lisa A.

AU - Daugherty, Alan

AU - Lu, Hong S.

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Aortic Aneurysms and Dissections Series: Part II: Dynamic Signaling Responses in Aortic Aneurysms and Dissections

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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