Aortic Aneurysms and Dissections Series: Part II: Dynamic Signaling Responses in Aortic Aneurysms and Dissections

Ying H. Shen, Scott A. LeMaire, Nancy R. Webb, Lisa A. Cassis, Alan Daugherty, Hong S. Lu

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Aortic structure and function are controlled by the coordinated actions of different aortic cells and the extracellular matrix. Several pathways have been identified that control the aortic wall in a cell-type-specific manner and play diverse roles in various phases of aortic injury, repair, and remodeling. This complexity of signaling in the aortic wall poses challenges to the development of therapeutic strategies for treating aortic aneurysms and dissections. Here, in part II of this Recent Highlights series on aortic aneurysms and dissections, we will summarize recent studies published in Arteriosclerosis, Thrombosis, and Vascular Biology that have contributed to our knowledge of the signaling pathway-related mechanisms of aortic aneurysms and dissections.

Original languageEnglish
Pages (from-to)E78-E86
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Issue number4
StatePublished - Apr 1 2020

Bibliographical note

Funding Information:
Our research activities are supported by grants from the National Institutes of Health (NIH)/National Heart, Lung, and Blood Institute (HL131980, HL143359, HL127111, HL133723, HL139748, HL134731, and HL107326) and from the American Heart Association (AHA) Vascular Diseases Strategically Focused Research Networks (SFRN; AHA18SFRN33960114, 33960163, and 33960253). The content in this article is solely the responsibility of the authors and does not necessarily represent the official views of the NIH and AHA. S.A. LeMaire’s work is supported in part by the Jimmy and Roberta Howell Professorship in Cardiovascular Surgery at Baylor College of Medicine.

Publisher Copyright:
© 2020 American Heart Association, Inc.


  • angiotensin II receptor
  • aorta
  • aortic aneurysms
  • signal transduction pathways
  • transforming growth factor

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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