Apigenin inhibits tumor angiogenesis through decreasing HIF-1α and VEGF expression

Jing Fang, Qiong Zhou, Ling Zhi Liu, Chang Xia, Xiaowen Hu, Xianglin Shi, Bing Hua Jiang

Research output: Contribution to journalArticlepeer-review

210 Scopus citations

Abstract

Apigenin is a non-toxic dietary flavonoid with anti-tumor properties. We recently showed that apigenin-inhibited hypoxia-inducible factor-1 (HIF-1) and vascular endothelial growth factor (VEGF) expression in human ovarian cancer cells under normoxic condition. However, the effect of apigenin in angiogenesis remains to be elucidated. Angiogenesis is the formation of new blood vessels and is required for tumor growth and metastasis. In this study, we showed that apigenin-inhibited expression of HIF-1 and VEGF in different cancer cells under both normoxic and hypoxic conditions. We demonstrated that apigenin significantly inhibited tumor angiogenesis in vivo, by using both the chicken chorioallantoic membrane and Matrigel plug assays. The inhibition of tumor angiogenesis was associated with the decrease of HIF-1 and VEGF in tumor tissues. Taken together, our results show that apigenin suppresses tumor angiogenesis through HIF-1 and VEGF expression.

Original languageEnglish
Pages (from-to)858-864
Number of pages7
JournalCarcinogenesis
Volume28
Issue number4
DOIs
StatePublished - Apr 2007

ASJC Scopus subject areas

  • Cancer Research

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